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Bing Su

Date:2020-05-19 show:


undefined Bing Su, Ph.D., Professor

 Director, Shanghai Institute of Immunology

 Chair, Department of Immunology and Microbiology,Shanghai Jiao Tong University School of Medicine

 Director, Immune and Microbiota Related Diseases Research Center of Shanghai Institute of Immunology & Shanghai General Hospital, Shanghai JiaoTong University School of Medicine

 Director,Shanghai Jiao Tong University School of Medicine-Yale University Immunometabolism Research Center (SYIRC)

 KC Wong Chair Professor, Shanghai Jiao Tong University

 Professor Adjunct to Department of Immunobiology, Yale University School of Medicine

The research in Dr.Su's laboratory focuses on the biology of signal transduction mediated by the intracellular protein kinase network such as the mitogen-activated protein kinase (MAPK) cascades and the mammalian target of rapamycine (mTOR) pathway in gut immune responses and in blood vessel function/development. They study the genes that encode either the serine/threonine kinases or their regulators in the kinase pathways. Their studies have revealed the roles of these kinase pathways in transducing various receptor signals and in regulating cell growth, differentiation, and apoptosis.

Education:

1991    Ph.D.    Yale University
1987    M.Ph.    Yale University    

1984    B.S.    Peking University

Work Experience:

2018-Present     Director, Shanghai Jiao Tong University School of Medicine-Yale University Immunometabolism Research Center (SYIRC)

2016-Present     Director, Immune and Microbiota Related Diseases Research Center of Shanghai Institute of Immunology & Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

2014-present     Adjunct Professor, Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale School of Medicine

2014-Present     KC Wong Endowed Chair Professor, Shanghai Jiaotong University

2014-present     Adjunct Professor, Yale School of Medicine

2013-Present     Professor and Chair, Department of Immunology and Microbiology, Shanghai Jiaotong University School of Medicine

2012-Present     Director and Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine

2009-2012     Guest Professor, Shanghai Jiaotong University School of Medicine

2007-2014     Associate Professor (Tenure), Yale School of Medicine and Graduate School of Arts & Sciences

2006-2006     Professor with Tenure, The University of Texas, MD Anderson Cancer Center

1995-2006     Assistant, Associate, and Full Professor, The University of Texas Health Science Center

1991-1995     Postdoctoral Fellow, University of California at San Diego

Publications:

1.  M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,B Su(Corresponding author).Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.Cell Mol Immunol,2019,10.1038/s41423-018-0185-x.   [Link]

2.   X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, Bing Su.(Corresponding author). Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 .J Mol Cell Biol,2018,11(2):93-106.   [Link]

3.  Xu YY, Ouyang XX, Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B(Corresponding author), and Liu JL..Sin1 regulates ischaemia-induced microthrombosis through integrin αIIbβ3-mediated outside-in signaling and hypoxia responses in platelet.Arteriosclerosis, Thrombosis, and Vascular Biology,2018,(in press).   [Link]

4.  Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B (Corresponding author) and Wu ZB..Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors.Nature Communications,2018,9:4624.   [Link]

5.  OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.(Corresponding author).Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression .J Immunol,2018,201:908-915..   [Link]

6.  Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang,Bing Su(Corresponding author) and Junling Liu.Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.Blood Adv,2018,26;2(12):1439-1448..   [Link]

7.  Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C Huang YH, Hamilton TA1,2, Su B(Corresponding author) and LiX..IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.J Immuno l,2017,199(11):3849-3857.   [Link]

8.  Tan R, Nakajima S, Wang Q, Sun H,Xue J, Wu J, Hellwig S, Zeng X, Yates NA7, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B(Corresponding author), Lan L..Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Mol Cell,2017 ,65(5):818-831.   [Link]

9.  Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B(Corresponding author), Li Y ..Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression .Oncotarget,2016,7(9):10064-72.   [Link]

10.  Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B.(Corresponding author).Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.Nat Commun,2015,6: 1-11.   [Link]

11.  Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B(Corresponding author), Wei W.PtdIns (3,4,5)P3-dependent activation of the mTORC2 kinase complex.Cancer Discov,2015,5(11):1194-209.   [Link]

12.  Chang X, Liu F, Wang X, Lin A, Zhao H, Su B.(Corresponding author).The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.Immunity,2011,34(2):201-12.   [Link]

13.  Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B(Corresponding author), and Estela Jacinto. . The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J,2008, 27(14):1932-43.   [Link]

14.  Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.(Corresponding author) .SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. . Cell, 2006, 127(1):125-37.   [Link]

15.  Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, and Su B. (Corresponding author).Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3. Nature Immunology,2004,5:95-103.   [Link]

16.  Yang J, Lin Y, Guo Z, Borem M, Huang H, Liao, Chen Z, Liu ZG, and Su B. (Corresponding author).Essential role of MEKK3 in TNF-induced NF-kB activation.Nature Immunology ,2001,2:620-624.   [Link]

17.  Su B.(First author), Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. .JNK mediates signal integration during costimulation of T lymphocytes. Cell .,1994, 77:727-736,.   [Link]