本实验室的主要研究兴趣集中在肿瘤免疫机理的探索及免疫治疗的开发上，专注于免疫细胞在肿瘤发生发展及肿瘤杀伤中的作用及调控，从淋巴细胞和髓系细胞同时入手，结合临床抗体研究和人源化动物模型开发，通过研究肿瘤免疫（Tumor immunity）和自身免疫（Autoimmunity）的分子机理，开发安全有效的肿瘤免疫治疗新抗体，新药物靶点，新化合物及联合疗法。

(1) Yan Zhang; Michael Morgan; Ken Chen; Swati Choksi; Zhenggang Liu*; Indu ction of Autophagy is Essential for Monocyte-Macrophage Differentiation, Blood, 2012, 119(12): 2895-2905.

(2) Yan Zhang; Swati Chokis; Kun Chen; Yelena Pobezinskaya; Ilona Linnoila; Zhenggang Liu*; ROS plays a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor associated macrophages, Cell Research, 2013, 23: 898-914.

(3) Yan Zhang; Swati Choksi; Zhenggang Liu*; Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis, Cancers, 2013, 5(4): 1643-1654.

(4) Yan Zhang#*; Xuexiang Du#; Mingyue Liu#; Fei Tang; Peng Zhang; Chunxia Ai; James K. Fields; Eric J. Sundberg; Olga S. Latinovic; Martin Devenport; Pan Zheng*; Yang Liu*; Hijacking Antibody-induced CTLA-4 Lysosomal Degradation for Safer and More Effective Cancer Immunotherapy, Cell Research, 2019, 29: 609-627.

(5) Wei Zheng#; Yan Zhang#; Jingjing Chen#; Yu Hu#; Pan Jia; Xuelei Wang; Qifang Zhao; Yicong Deng; Ni Li; Yi Zhang; Jun Qin; Xiaoming Wang*; Wei Lu*; Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway, Science Immunology, 2019, 4(41).