上海交通大学医学院附属仁济医院临床干细胞研究中心，成立于2010年，由仁济医院和上海交通大学Med-X研究院共同创建。研究中心坐落于仁济医院东院17号楼15楼，实验空间1000平方米。截止2020年底，设有研究组8个，科技人员40人。具有高级专业技术职称者15人，研究生导师15人（博导7人、硕导8人），招生专业为肿瘤学和基础医学，现有在读研究生30人（博士生17人、硕士生13人），在站博士后7人。
研究中心的主要研究方向为干细胞与组织修复；肿瘤干细胞与肿瘤发生发展。八个研究组包括现任中心主任高维强教授领衔的“干细胞与组织修复及肿瘤发生研究室”、冯海忠研究员领衔的“肿瘤转移与肿瘤干细胞研究室”、朱鹤研究员领衔的“成体干细胞和肿瘤干细胞研究室”、薛婧研究员领衔的“炎症与炎症相关肿瘤研究室”、庄光磊研究员领衔的“肿瘤动态演进与靶向治疗研究室”、蔡志伟研究员领衔的“前列腺肿瘤生物学与模式创建研究室”、桂俊研究员领衔的“肿瘤免疫学研究室”和刘艳丰研究员领衔的“细胞代谢与肿瘤转移室”。研究涉及干细胞分裂模式、干细胞干性维持、组织干细胞的异质性分析、组织干细胞作为癌起源细胞的能力验证、肿瘤干细胞和上皮间质转化、免疫与肿瘤及细胞代谢与肿瘤转移等多个领域。
成立以来，研究中心发展十分迅速。截止2020年底，先后主持72项国家级项目和53项省部级项目，科研经费突破了1亿元。其中，科技部国家重大科学研究计划/国家重点研发计划项目首席2项及课题2项，国家自然科学基金重点项目3项，优青项目3项，面上项目40项，青年项目22项，外国青年项目2项。科研成效显现，产出了一批有影响的重要科研成果，共发表SCI论文147篇，其中影响因子≥10的22篇，5≤影响因子<10的63篇，包括Gastroenterology、Nature Communications、Cell Research、Gut、PNAS, Clinical Cancer Research等高质量杂志论文，并申请专利10项，授权2项。
The Clinical Stem Cell Research Center was established in 2010 and was co-founded by Ren Ji Hospital and Med-X Research Institute of Shanghai Jiao Tong University. The center is located in Building no. 17 of the East Campus of Ren Ji Hospital, with a laboratory space of 1000 square meters. By the end of 2020, there are 8 research groups and 40 staffs, including 15 associate/full professors, 15 graduate student mentors (7 doctoral supervisors and 8 master supervisors); Enrollment major: Oncology and Basic Medical Science). Currently, the center has 30 graduate students (17 doctoral students and 13 master students) and 7 postdoctors.
The main research areas of the Clinical Stem Cell Research Center are stem cell and tissue repair; tumor stem cells and tumor development. The eight research groups include the "Laboratory of Stem Cells in Tissue Repair and Tumor" led by Professor Wei-Qiang Gao (current director of the center), the "Laboratory of Tumor Metastasis and Cancer Stem Cell" led by Professor Hai-zhong Feng, the "Laboratory of Tissue Stem Cells and Tumor Stem Cells" led by Professor Helen He Zhu, the "Laboratory of Inflammation and Tumorigenesis" led by Professor Jing Xue, the "Laboratory of tumor dynamic evolution and targeted therapy " led by Professor Guang-lei Zhuang, the "Laboratory of Prostate Tumor Biology and Modeling" led by Professor Chee Wai Chua, the "Laboratory of tumor Immunology " led by Professor Jun Gui, the "Laboratory of cell metabolism and tumor metastasis" led by Professor Yan-feng Liu.
In particular, research topics that are actively investigated include stem cell division modes, stemness regulation, tissue stem cell heterogeneity, cells-of-origins of cancer, cancer stem cells, epithelial-mesenchymal transition, tumor immunity and cell metabolism and tumor metastasis.
Since its establishment, the Clinical Stem Cell Research Center has progressed rapidly. By the end of 2020, it has obtained 72 national-level grants and 53 provincial-level grants. The total research funding has exceeded 100 million Chinese Yuan. These include 2 National Key R&D Program Grant of China, 3 key grants from National Natural Science Foundation (NSFC), 3 NSFC excellent youth grants, 40 NSFC regular grants, 22 NSFC youth grants, 2 NSFC foreign youth grants. A number of important scientific research achievements with international influence have been produced, including 147 SCI publications in SCI journals, 22 papers with Impact Factor≥10 and 63 papers with 5≤Impact Factor<10, including publications in Gastroenterology, Nature Communications, Cell Research, PNAS and Clinical Cancer Research), together with 10 filed patents and 2 granted patents.
