上海交通大学医学院组织胚胎学与遗传发育学系成立于2017年6月，由原解剖学与组织胚胎学系中的组织胚胎学学科，原分子发育生物学研究室、原发育生物学研究室及原医学遗传学教研室重组而成。唐玉杰研究员任系主任，张明亮研究员任党支部书记、常务副主任，黄雷教授和伍静文副教授任副主任。
作为上海交通大学医学院的重点发展学科之一，组织胚胎学与遗传发育学系，在科研布局上力求契合现代再生医学发展的新趋势，综合生命科学、基础医学、化学生物学、生物医学工程及材料科学等相关研究领域，依托上海市生殖医学重点实验室，聚焦生殖医学、发育与干细胞生物学、遗传疾病与儿童肿瘤三大科研方向，包括从配子发生、胚胎早期发育到发育异常引起的遗传疾病与儿童肿瘤；以及从干细胞干性维持和定向分化以及发育异常疾病相关的细胞命运调控等重要生物学问题的机制研究，到基于细胞重编程、基因编辑、单细胞测序和3D培养等技术的疾病模拟和药物筛选。将围绕关系国计民生的关键科学问题和技术手段，着力解决生命早期发育以及发育异常相关重大疾病的机制研究、技术开发和临床转化问题。
我系坚持积极引进和培养杰出人才，现已经初步形成了一支结构合理、具有较强科研实力和创新能力的人才队伍。截至2021年12月，我系共有教职员工37人，其中正高8人，副高10人，59.5%具有博士学位；形成了8个研究团队，包括科技部重点研发项目负责人1人，国家高层次人才计划3人，国家高层次人才计划青年项目1人，国家杰出青年科学基金获得者1人，上海市优秀学科/术带头人2人，上海市领军人才2人，上海市“曙光学者”2人，上海市青年“科技启明星”1人，上海市“浦江人才”4人，上海高层次人才计划6人次。近年来在包括Nature，Cancer Cell，Cell Stem Cell，JCI，Blood，Cell Res，Dev Cell，PNAS等在内的国际顶尖生物医学学术期刊上发表过多篇研究论文，并获得了国家和上海市层面的多个科研项目支持，现有科研基金超过3000万。
本系将不断促进基础医学院学科发展与学科间的相互交流与融合，并通过持续改革教学形式和教学内容为培养卓越医学人才奠定良好基础。鉴于学科发展的迫切需求，本系常年进行人才招聘，积极邀请有志从事生殖医学、发育与干细胞生物学、遗传疾病与儿童肿瘤方向科学研究的优秀海内外学者加盟。
Department of Histoembryology, Genetics and Developmental Biology
Established in the June of 2017, the Department of Histoembryology, Genetics and Developmental Biology (DHGDB) combines following original departments in the Basic Medical College: Histoembryology, Molecular Developmental Biology Laboratory, Developmental Biology Laboratory and the Teaching and Research Office of the Medical Genetics. Dr. YuJie Tang is the director of the department. Dr. Mingliang Zhang is the party branch secretary and executive deputy director. Dr. Lei Huang and Dr. Jingwen Wu are the deputy directors.
Following the latest international medical research trends, as one of the major research directions in Shanghai Jiao Tong University School of Medicine, and relying on Shanghai Key Laboratory of Reproductive Medicine, DHGDB has drawn strengths in a series of cutting-edge basic and translational research areas, including life science, basic medical research, chemical biology, material science, and focuses the scientific research on reproductive medicine, developmental and stem cell biology, genetics and pediatric cancer, exploring the mechanisms underlying gametogenesis, embryonic development, and genetic disorders and pediatric cancer. Supported by state-of-art core facilities / platforms of cellular reprogramming, gene editing, single-cell genomics, and 3D / live cell technology. Our scientists have made every effort to work against the devastating illness, perform the disease modeling, and develop the novel drugs. Our mission is to decode biomedical knowledge and bring the patient perspective to our work.
DHGDB has attracted and retained distinguished scholars who are committed to teaching and academic pursuits, with 37 faculty and staff members at present, including 8 full professors, 10 associated professors, and 59.5% percent of them are Ph.D or M.D. By the end of 2021, we have one project leaders of the Key Research and Development Projects of the Ministry of Science and Technology, three winners of National High-level Talent Plan, one winner of National High-level Youth Talent Plan, one Distinguished Young Scholar funded by the National Natural Science Foundation, two Shanghai Outstanding Academic Leaders, two Shanghai Leading Talents, two Shanghai "Dawn Scholars", one Shanghai Rising-Star Program, four Shanghai "Pujiang Talents", six Shanghai Program for High-Level Talents Introduction. So far, DHGDB with a total of ￥30 million in scientific research funds, has published numerous research articles in internationally highly respected journals, including Nature，Cancer Cell , Cell Stem Cell, JCI, Blood, Cell Res., Dev Cell, and PNAS.
The department will continue to make contributions to the development of the Basic Medical College, interdisciplinary communication and integration, to the reform of teaching methods and contents, which will build a solid foundation for cultivating outstanding medical talents. Meanwhile, we are open to scholars at home and abroad, recruiting qualified talents, who are interested in the research in the fields of reproductive medicine, genetics, developmental and stem cell biology, genetic disorders and pediatric cancer.
