病理生理学系是在上海第二医科大学基础医学院病理生理学教研室的基础上发展而来。该教研室于1956年在章德馨副教授领导下建立。1977-1989年间，上海第二医科大学校长王振义教授（1992年任法国科学院外籍院士，1994年任中国工程院院士，获得2010年度国家最高科学技术奖）担任教研室主任，相关工作先后获得了上海市科学技术进步二等奖、中医药科技进步三等奖、上海市卫生系统“银蛇奖”等一批科技奖项，该学科也于1984年成为首批上海市地方高校重点学科。进入上世纪90年代后，徐也鲁教授和张启良教授先后担任教研室主任。2000年该学科成为博士点学科。2002年，国家杰出青年基金获得者、上海市十大杰出青年陈国强教授（2015年任中国科学院院士）担任学科带头人，开始新一轮的以内涵建设和创新人才培养为核心的学科建设。致力于白血病细胞分化和凋亡化学生物学研究，成为211工程重点建设学科和国家重点学科，并获得“全国工人先锋号”、“上海市教育系统文明组室”、“上海市文明班组”、“上海市劳模集体”等称号。2018年钟清研究员在病理生理学教研室的基础上正式成立病理生理学系并担任系主任。
系主任全面负责实验室的总体运行，实行民主管理、研究组长负责制，制定学科发展计划，对各研究组在人才培养、科研投入、科研产出等方面实现目标责任制。目前，本系在职人员55名，70%以上拥有博士学位和海外工作经历，正高职称19名（含三位没有正式职称的PI），副高职称10名。中国科学院院士1人，国家高层次人才计划3人，国家高层次人才计划青年项目5人，上海市高层次人才2人，国家杰出青年科学基金获得者3人，国家自然科学基金委优秀青年基金获得者3人。
病理生理学系围绕肿瘤细胞命运决定的医学生物学研究及靶向治疗等方向，开展多学科交叉，系统开展发病学及治疗学的基础和转化医学研究。先后承担包括国家科技部十二五支撑计划、“973”计划和“863”计划、国家自然科学基金重大集成、重点、面上项目和上海市科研项目等200余项，取得系列重要发现，在国际权威学术刊物Nature、Cell Metabolism、Cancer Cell、Nature Chemical Biology、Nature Cell Biology、PNAS、Blood等发表SCI论文300余篇，并获得国家自然科学二等奖、中华医学科技一等奖、上海市科技进步一等奖、上海市自然科学一等奖等奖项。授权六项发明专利。期间，病理生理学系共培养了120余位硕、博士研究生，并有多名学生获国家及地方优秀研究生奖励。
Department of Pathophysiology
【Development History】
The Department of Pathophysiology was established by Associate Professor Zhang Dexin in Shanghai Jiaotong University School of Medicine (formerly Shanghai Second Medical University) in 1956. Between 1977 and 1989, Professor Wang Zhenyi, President of the University (foreign academician of the French Academy of Sciences in 1992 and an academician of the Chinese Academy of Engineering in 1994，winner of the State Preeminent Science and Technology Award in 2010) served as the chair of the department, dedicated to the study of atherosclerosis and hemostasis and thrombosis, and achieved a series of extraordinary results, which has won the second prize of Shanghai Science and Technology Progress Award, the third prize of Traditional Chinese Medicine Science and Technology Progress Award, the Shanghai Health System “Silver Snake Award” and etc. The discipline was also among the first to be the core subject of Shanghai city universities in 1984.
Ever since the 1990s, Professor Xu Yelu and Professor Zhang Qiliang served successively as chairs of the department, which became a doctoral discipline in 2000. In 2002, Prof. Chen Guoqiang, the winner of the National Science Fund for Distinguished Young Scholars and one of Shanghai's Top Ten Outstanding Young People, took the lead and initiated the discipline construction focusing on connotation construction and innovative talent cultivation. Adhering to the scientific innovation spirit of “courageous to think, speak and operate with perseverance and dedication”, the research direction was focused on leukemia cell differentiation and apoptosis, chemical biology, proteomics, leukemia etiology. The department under his leadership has won many honors. The pathology discipline became the key discipline of 211 projects and one of the national key disciplines. The research team won the "National Working Leading Organization", "Shanghai Education System Distinguished Group", "Shanghai Outstanding Team", "Shanghai Model Team" and other titles. In 2018, Dr. Zhong Qing served as the chair of the Department of Pathophysiology.
【Team of Expertise】
The chair of the department is dedicated to the overall operation of the laboratory, implementing democratic management, research team leader responsibility system, formulating the discipline development plan, and setting the work objectives and incentive mechanism in terms of personnel training, scientific research input & output. Meanwhile, outstanding young scholars are encouraged to cooperate with internationally renowned scholars to carry out high-level cooperative research, and on the other side, the department is open to cooperation. Currently, the department is composed of 55 in-service staff, more than 70% of whom have doctoral degrees and overseas work experience, 19 of full investigators and 10 associate investigators, 1 academician of the Chinese Academy of Sciences, 3 National High-level Talent Plan, 5 National High-level Youth Talent Plan, 3 National Distinguished Young Scholars winners, 3 Outstanding Youth Fund winners of the National Natural Science Foundation of China, 2 High-Level Talent Programs of Shanghai.
【Research Overview】
The Department of Pathophysiology is involved in biomedical research areas that span a broad range of tumor cell fate determination, including mechanisms of initiation and development of solid tumors and hematopoietic tumors, hematopoietic and leukemia stem cells, tumor molecular markers research and targeted therapy, disease proteomics, structural biology and bioinformatics, and basic research on cardiovascular and cerebrovascular diseases, etc. The department carries out basic and translational medical research in pathogenesis and therapeutics with the multidisciplinary and cross-disciplinary principle. The department has undertaken more than 200 projects including the 12th Five-Year Support Plan of the Ministry of Science and Technology, the "973" Plan and the "863" Plan, the National Natural Science Foundation's Major Integration, Key Project, General Projects and Shanghai Research Projects. Nearly 300 SCI papers were published on the internationally high-profile academic journals such as Nature, Cell metabolism, Cancer Cell, Nature Chemical Biology, Nature Cell Biology, Nature Communication, PNAS, Blood, etc. In addition, the department has won the second prize of the National Natural Science Award, the first prize of China Medical Science and Technology, the Shanghai Science and Technology Progress Award, Shanghai Natural Science First Prize and other awards. Six patents have been authorized. The Department of Pathophysiology has trained more than 120 masters and doctoral students, one of whom won 100 National Excellent Doctoral Thesis, 7 the Shanghai Graduate Outstanding Achievement Award, and 1 the Wurui Scholarship.
