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上海精准医学研究院

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上海精准医学研究院(以下简称“精准院”)属于上海市教委IV类高峰学科建设项目,是由上海交通大学医学院牵头、依托上海交通大学医学院附属第九人民医院进行实体化建设的上海市科技协同创新中心。精准院由雷鸣研究员任执行院长,已建成蛋白质平台、组学平台、电镜平台、生物成像平台、化学生物学平台、数据计算与分析平台。目前,精准院已经形成一支由多名中青年独立研究员组成的科研队伍,在干细胞与再生医学、组织工程、病原微生物、生殖与遗传发育、肿瘤与代谢性疾病、组学、结构生物学、生物信息学等与精准医学密切相关的研究领域全面展开科研探索,同时与哈佛大学医学院、耶鲁大学医学院以及密歇根大学展开广泛的国际合作与学生交流活动,致力于成为有全球影响力的精准医学研究基地。

Shanghai Institute of Precision Medicine (SHIPM) is established in August 2016 to align with the goal of developing Shanghai into a science innovation center. SHIPM belongs to Shanghai Jiao Tong University School of Medicine and is affiliated with Shanghai 9th People’s Hospital. Dr. Ming Lei is the Executive Director of SHIPM. As a subsidiary institute to Shanghai Jiao Tong University School of Medicine, SHIPM has built its scientific research team dedicated to promoting the precision prevention, diagnosis and therapy against severe chronic diseases threatening human health, such as cancer, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, etc., by orchestrating the power of the basic and translational research to address questions in life science. SHIPM has established six cutting-edge research facilities in the fields of Protein Engineering, Mass Spectroscopy, Electron Microscopy, Bio-imaging, Chemical Biology and Bioinformatics. In an effort to become a precision medicine research hub with global influence, SHIPM is conducting extensive international cooperation and students exchange activities with Harvard Medical School, Yale Medical School and the University of Michigan.

 

l 领导 / Leadership

 

院长:

吴皓  博士

教授,主任医生,博士生导师

上海交通大学医学院附属第九人民医院院长

上海交通大学医学院耳科学研究所所长

上海交通大学医学院耳鼻喉科学系系主任

上海市耳鼻喉科临床中量控制中心主任

上海市儿童听力障碍诊治中心主任

Director

WU Hao / 吴皓

Professor, Shanghai Jiao Tong University School of Medicine

President, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

Director, Ear Institute, Shanghai Jiao Tong University School of Medicine

Chair, Department of Otolaryngology Head and Neck Surgery, Shanghai Jiao Tong University School of Medicine

 

执行院长:

雷鸣  博士

研究员,博士生导师

国家杰出青年科学基金项目获得者

亚太蛋白质协会执行委员

中国生物物理协会副理事长

中国蛋白质协会副理事长

Science Bulletin杂志执行主编

Executive Director

LEI Ming / 雷鸣

Professor, Shanghai Jiao Tong University School of Medicine

The National Science Fund for Distinguished Young Scholars

Council Member, Asia Pacific Protein Association

Executive Editor, Science Bulletin

l 主要研究领域 / Research Fields

生殖医学与染色体研究

Reproductive Medicine & Chromatin

再生医学与发育研究

Regenerative Medicine & Development

肿瘤医学与表观遗传学研究

Cancer Medicine & Epigenetics

骨科医学与合成生物学研究

Osteopathic Medicine & Synthetic Biology

分子病理学与靶向药物

Molecular Pathology & Targeted Medicines

耳科/眼科医学与脑科学研究

Otology / Ophthalmology & Brain Science

l 科研团队 / Our Research Team

 

卞迁

职位:研究员,研究组长博士生导师

研究方向:三维基因组结构、表观遗传学、衰老的生物学机制

Dr. BIAN Qian

Ph.D., Professor, Principal Investigator

Research Focus: 3D Genome Architecture, Epigenetics, Ageing

 

曹禹

职位:研究员,研究组长,博士生导师

研究方向:跨膜生物过程的分子机制;大分子药物开发

Dr. CAO Yu,

Professor, Principal Investigator

Research Focus: Metabolic process within membrane; drug discovery

 

华云峰

职位:研究员,研究组长,博士生导师

研究方向:大脑感官皮层三维超微结构

Dr. HUA Yunfeng

Professor, Principal Investigator

Research Focus: Study neuronal circuit ultrastructural basis of auditory brain function and diseases

 

黄晶

职位:研究员,研究组长,博士生导师

研究方向:肿瘤发生发展的表观遗传机制及靶向药物研发

Dr. HUANG Jing

Professor, Principal Investigator

Research Focus: Epigenetics and Cancer Biology

 

雷鸣

职位:研究员,研究组长,博士生导师

国家杰出青年科学基金项目获得者

研究方向:染色质结构与衰老分子机制

Dr. LEI Ming,

Executive Director, Professor, Principal Investigator

The National Science Fund for Distinguished Young Scholars

Research Focus: Telomere and chromosomal stability; chromatin structure and cancer

 

武健

职位:研究员,研究组长,博士生导师

研究方向:长非编码RNA-蛋白质复合物的结构与功能

Dr. WU Jian,

Professor, co-Principal Investigator

Research Focus: Structure and Function of Long non-coding RNA in Complex with Proteins

 

 

陈善双

职位:研究员,研究组长,博士生导师
研究方向:神经突触离子通道的结构与功能

Dr.CHEN Shanshuang

Professor, Principal Investigator

Research FocusStructural and functional investigation of synaptic ion-channels

 

于士颜

职位:研究员,研究组长
研究方向:宿主-微生物相互作用,组织干细胞生物学

Dr.YU Shiyan

Professor, Principal Investigator

Research FocusHost-Microbe Interactions, Tissue Stem Cell Biology

 

张燕捷

职位:主任医师,研究组长,博士生导师
研究方向:肿瘤靶向治疗与耐药机制的基础及临床研究

Dr.ZHANG Yanjie

Chief physician, Principal Investigator

Research FocusBasic and clinical research on tumor targeted therapy and drug resistance mechanism

 

 

张家毓

职位:研究员,研究组长

研究方向:遗传性心脏病发展机制的生物学研究;诱导性干细胞及小鼠为基础的心肌力学理模型研究; 抗心肌衰老药物研究

Dr. CHANG Chia-Yu,

Professor, Principal Investigator

Research Focus: Genetic cardiomyopathy; hiPSC-CM; biomechanics of cardiomyocyte contraction; drug development

 

 

 

曾汉林

职位:研究员,研究组长,博士生导师
研究方向:肿瘤遗传学进化、表型可塑性及耐药机制研究
Dr.ZENG Hanlin.

Professor, Principal Investigator

Research Focus:Genetic and non-genetic evolution of skin and mucosal cancers; Cancer cell plasticity & drug resistance

 

l 设施 / Our Facility

 

为支持科研发展,目前精准院已建成包括蛋白质平台、组学平台、电镜平台、生物成像平台、化学生物学平台、数据计算与分析平台等六大国际先进的科研设施平台。

To support the R&D activities, SHIPM has established six cutting-edge research facilities in the fields of Protein Engineering, Mass Spectroscopy, Electron Microscopy, Bio-imaging, Chemical Biology and Bioinformatics.

 

地址:上海市浦东新区锦尊路1152号楼,200125

电话:86-21-38452290

网址:www.shipm.cn

邮箱:hrshipm@shsmu.edu.cn

 

Address: 115 Jinzun Road, Building #2, Pudong District, Shanghai 200125, China

Tel: 86-21-38452290

Website: www.shipm.cn

Email: hrshipm@shsmu.edu.cn

 


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