上海市重性精神病重点实验室简介（中英文）
上海市重性精神病重点实验室于 2013年 9月由上海市科委批准建设，2015年 9 月通过市科委验收，是上海市精神卫生中心基础研究平台重要组成部分之一。上海市重性精神病重点实验室现任主任为徐一峰教授、执行主任为崔东红研究员，学术委员会主任为贺林院士。重点实验室目前在徐汇及闵行两个院区均有实验室，在闵行院区的重点实验室平台办公面积为6000平米的实验大楼，已建成有分子生物学平台、细胞生物学平台、动物行为学平台、离体、在体电生理平台、共聚焦成像平台、人脑电生理及磁共振平台、样本库平台等14个技术平台，每个平台都配备了先进的仪器设备和专业的科研人员进行管理。在依托单位上海市精神卫生中心及申康医院管理中心的支持下，重点实验室闵行院区实验平台目前已拥有总计价值三千多万的仪器设备。平台不但承担了精神卫生中心院内各科室和研究组的科研任务，还对外向交大系统内附属医院以及全市范围内的科研机构提供技术服务。
自2016年开始，重点实验室每年在科研成果产出方面与交大系统内二十多家同类市级重点实验室相比，均处于上游水平，近三年来发表的高影响因子论文杂志包括（Nat Genet、Nat Neurosci、Nat Commun、JAMA Psychiatry、Cell Res、 J Clin Invest 、Am J Psychiatry、Mol Psychiatry、Sci Adv、Lancet Psychiatry等），近三年来重点实验室成员获得的国家级项目包括：国家科技重大专项、科技部重点专项、国家自然科学基金、基金委国际（地区）合作基金等。还有多人获得基金委优秀青年科学项目基金、上海市领军人才、上海市优秀学科带头人、上海市科技青年启明星、上海市扬帆计划等。成绩是过往奋斗与汗水的证明，也激励着全体成员为了实验室今后的发展更加拼搏向上。
2016年，重点实验室各课题组成员发表或参与发表SCI/EI论文110篇，其中影响因子10分以上2篇；在研项目77项，其中国家级项目24项，合同经费总额4300多万元；研究生培养人数70多人；出版专著5部；申请/授权专利1项；主办/承办大型学术会议3次。
2017年，重点实验室各课题组成员发表或参与发表SCI/EI论文80多篇，其中影响因子10分以上8篇；在研项目105项，其中国家级项目28项，合同经费总额6600多万元；研究生培养人数80多人；出版专著9部；申请/授权专利5项；获得上海市科技进步三等奖1项；主办/承办大型学术会议8次。
2018年，重点实验室各课题组成员发表或参与发表SCI/EI论文120篇，其中影响因子10分以上10篇；在研项目98项，其中国家级项目29项，合同经费总额1.16亿元；研究生培养人数90多人；出版专著3部；申请/授权专利6项；主办/承办大型学术会议4次。
重点实验室各课题组目前还与国外众多大学及科研机构如耶鲁大学、哈佛大学医学院、明尼苏达大学、密歇根大学、加拿大纪念大学、英国国王学院等开展科研合作。
重点实验室从成立初始的30多名成员，经过5年建设，目前有固定工作人员 88人，其中学术带头人9人，科研人员 64人，技术人员24人。 在固定人员中，拥有博士及以上学历成员占总人数的57%；高级职称成员占总人数的47%；30-45岁成员占总人数的75%。与此同时实验室还聘有国内外客座教授 14人。团队成员的年轻化、高学历和海外留学背景使得整个研究队伍呈现出“ 高、精、尖 ”的特点。 “ 以国家中长期科学技术发展规划为指针， 根据国家发展重大需求和脑科学发展前沿，围绕精神疾病，凝炼研究方向，开展基础 以及与临床结合的应用研究 ”是重点实验室的中长期发展目标。上海市重性精神病重点实验室正致力于将平台打造成本领域以及国内外有影响力的高层次人才培养和科研基地。
重点实验室的985精神疾病生物样本库平台，还与国内13家精神疾病专科医院签署了合作协议，共同打造国内最大的精神疾病生物样本库。生物样本库采取信息化、规范化、标准化管理模式，从2016年开始，生物样本库库存样本数量每年以25%的增长速度增加。至2018年底，样本总数为60000份，捐赠者为3950人。捐献者类型包括健康人群、精神分裂症、痴呆、物质依赖、抑郁症、躁狂症、双相情感障碍及其他等。样本种类为血浆、血清、红细胞、血凝块、DNA、RNA、尿液等。为了确保临床样本采集的规范化，生物样本库自2015年下半年开始就成立了样本库临床专员队伍，临床专员由病房中的护士长助理担任，样本库定期对临床专员进行培训，主要内容为精神科各类量表的评估、捐献者的选择、知情同意书的签署等等，这样能确保入库的每份样本均有相匹配的完整的临床信息。样本库还根据不同的疾病制定了相应的CRF表，一份完整有效地样本，包括知情同意书、一般信息、相应的量表信息、唯一的ID编码，确保每份样本的有效性。生物样本库于2016年通过本院伦理委员会的伦理审查，之后每年均申请并通过本院伦理委员会的跟踪伦理审查。
Shanghai key laboratory of psychotic disorder (referred as "Key laboratory" below) was established with the sanction of Shanghai Science and Technology Commission in September 2013, and passed the evaluation and acceptance by the Commission in September 2015. Key laboratory is one of the important basic research platform of Shanghai Mental Health Center (SMHC). Laboratory Chief, Professor Yifeng Xu; executive director, Professor Donghong Cui; director of Academic committee, National academician Lin He. Key laboratory has an experimental building of 6000 square meters in Minhang branch with several platforms including molecular biology platform; cell biology platform; animal behavior platform; in vitro and in vivo electrophysiology platform; confocal imaging platform; optical genetic platform; metabonomic and proteome platform; human brain electrophysiology and MRI platform; and sample bank platform ,etc. Each platform is equipped with advanced instrumentation and managed by professional researchers. With the support of Shanghai Mental Health Center and Shenkang Hospital Management Center, Key laboratory has already been equiped with instrumentation of more than thirty million yuan. Key laboratory has not only undertaken the scientific research tasks of the departments and research groups in SMHC, but also provided technical services to the affiliated hospitals of Shanghai Jiao-Tong University and scientific research institutes throughout the city.
Since 2016, key laboratories have been in the upstream level in terms of scientific research annual output compared with more than 20 similar municipal key laboratories in the Jiaotong University system. In the past three years, researchers of Key laboratory published papers in journals with high impact factor including Nat Genet, Nat Neurosci, Nat Commun, JAMA Psychiatry, Cell Res, J Clin Invest, Am J Psychiatry, Mol Psychiatry, Sci Adv, Lan. Cet Psychiatry et al; have been awarded national-level projects, including major national science and technology projects, key projects of the Ministry of Science and Technology, the National Natural Science Foundation of China and the International (Regional) Cooperation Fund of the Foundation Committee and also fundings of Excellent Youth Science Project, Shanghai Leading Talents, Shanghai Excellent Discipline Leaders, Shanghai Science and Technology Youth Star, Shanghai Sailing Program and so on. In the past three years, members of key laboratories have obtained national projects including major national science and technology projects, key projects of the Ministry of Science and Technology, National Natural Science Foundation of China, international (regional) cooperation funds of the Foundation Committee, etc. There are also many people who have received the Fund for Excellent Youth Science Project, Shanghai Leading Talents, Shanghai Excellent Discipline Leaders, Shanghai Science and Technology Youth Star, Shanghai Sailing Plan and so on.
In 2016, 110 SCI/EI papers were published or participated in by members of key laboratory research groups, including 2 papers with more than 10 influencing factors; 77 research projects, including 24 national-level projects with total contract funds of more than 430 million yuan; more than 70 graduate students trained; 5 publishing monographs; 1 patent application/authorization; and 3 large-scale academic conferences sponsored/hosted.
In 2017, more than 80 SCI/EI papers were published or participated in by members of key laboratory research groups, including 8 papers with more than 10 influencing factors; 105 research projects, including 28 national-level projects with a total contract fund of more than 660 million yuan; more than 80 graduate students trained; 9 publications; 5 applications/authorized patents; 1 third-class award for scientific and technological progress in Shanghai; and 1 sponsor/undertake large-scale universities. There were 8 technical meetings.
In 2018, 120 SCI/EI papers were published or participated in by members of key laboratory research groups, including more than 10 papers with impact factors; 98 research projects, including 29 national projects with total contract funds of 116 million yuan; more than 90 graduate students trained; 3 publishing monographs; 6 applications/authorized patents; and 4 large-scale academic conferences sponsored/hosted.
At present, the research teams of the Key Laboratory also cooperate with many foreign universities and scientific research institutions, such as Yale University, Harvard Medical College, University of Minnesota, University of Michigan, Memorial University of Canada, King's College of England and so on.
At present, there are 88 fixed personnel in key laboratory, including academic leaders, 9; researchers, 64; technicians, 24. Among the fixed personnel, 57% of them have doctoral degree or above, 47% have senior title, and 75% are 30-45 years old. At the same time, the laboratory also employs 14 visiting professors at home and abroad. The research team of Key laboratory trends to be younger, with higher educational and more overseas background, which makes the team "high-grade, precision and advanced". At present, Key laboratory has formed a scientific research team which centers on research and technological personnel and graduate students. The medium to long-term objectives of Key laboratory is “ to take the national medium and long-term scientific and technological development plan as the index, to keep in line with the major requirements of national development and the frontiers of brain science development, to concentrate upon mental disorders; to refine research directions; and to carry out fundamental and clinical applied studies”. All the members of Key laboratory are working hard to achieve the objectives in near future.
The 985 Psychiatric Biological Sample Bank Platform of the Key Laboratory has also signed cooperation agreements with 13 psychiatric hospitals in China to jointly build the largest psychiatric biological sample bank in China. Biological sample bank adopts informatization, standardization and standardization management mode. Sice 2016, the number of biological smaple bank stock has increased by 25% annually. By the end of 2018, the total number of samples was 60,000, with 3,950 donors. Donors include healthy individuals and patients with schizophrenia, dementia, material dependence, depression, mania, bipolar disorder and other mental disorders. The samples include plasma, serum, erythrocyte, blood clot, DNA, RNA, urine and so on. In order to ensure the standardization of clinical sample collection, a team of clinical specialists has been set up since the second half of 2015. The clinical specialists are assistant head nurses in the ward. The clinical specialists are regularly trained in the sample bank. The main contents of the training include the evaluation of various psychiatric scales, the selection of donors, the signing of informed consent and so on. The sample bank also formulates corresponding CRF tables according to different diseases. A complete and effective sample includes informed consent, general information, corresponding scale information and unique ID coding. The Biological Sample Bank passed the ethical review by the Ethics Committee of the College in 2016, and then applied for and passed the follow-up ethical review by the Ethics Committee of the College every year.
