地址：上海市浦东新区锦尊路115号2号楼，200125
电话：86-21-38452290
网址：www.shipm.cn
邮箱：hrshipm@shsmu.edu.cn
Address: 115 Jinzun Road, Building #2, Pudong District, Shanghai 200125, China
Tel: 86-21-38452290
Website: www.shipm.cn
Email: hrshipm@shsmu.edu.cn
l 上海精准医学研究院简介 / Introduction
上海精准医学研究院（以下简称“精准院”）属于上海市教委IV类高峰学科建设项目，是由上海交通大学医学院牵头、依托上海交通大学医学院附属第九人民医院进行实体化建设的上海市科技协同创新中心。精准院由雷鸣研究员任执行院长，已建成蛋白质平台、组学平台、电镜平台、生物成像平台、化学生物学平台、数据计算与分析平台。目前，精准院已经形成一支由多名中青年独立研究员组成的科研队伍，在干细胞与再生医学、组织工程、病原微生物、生殖与遗传发育、肿瘤与代谢性疾病、组学、结构生物学、生物信息学等与精准医学密切相关的研究领域全面展开科研探索，同时与哈佛大学医学院、耶鲁大学医学院以及密歇根大学展开广泛的国际合作与学生交流活动，致力于成为有全球影响力的精准医学研究基地。
Shanghai Institute of Precision Medicine (SHIPM) is established in August 2016 to align with the goal of developing Shanghai into a science innovation center. SHIPM belongs to Shanghai Jiao Tong University School of Medicine and is affiliated with Shanghai 9th People’s Hospital. Dr. Ming Lei is the Executive Director of SHIPM. As a subsidiary institute to Shanghai Jiao Tong University School of Medicine, SHIPM has built its scientific research team dedicated to promoting the precision prevention, diagnosis and therapy against severe chronic diseases threatening human health, such as cancer, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, etc., by orchestrating the power of the basic and translational research to address questions in life science. SHIPM has established six cutting-edge research facilities in the fields of Protein Engineering, Mass Spectroscopy, Electron Microscopy, Bio-imaging, Chemical Biology and Bioinformatics. In an effort to become a precision medicine research hub with global influence, SHIPM is conducting extensive international cooperation and students exchange activities with Harvard Medical School, Yale Medical School and the University of Michigan.
l 领导 / Leadership
院长：
吴皓 博士
教授，主任医生，博士生导师
上海交通大学医学院附属第九人民医院院长
上海交通大学医学院耳科学研究所所长
上海交通大学医学院耳鼻喉科学系系主任
上海市耳鼻喉科临床中量控制中心主任
上海市儿童听力障碍诊治中心主任
Director
WU Hao / 吴皓
Professor, Shanghai Jiao Tong University School of Medicine
President, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Director, Ear Institute, Shanghai Jiao Tong University School of Medicine
Chair, Department of Otolaryngology Head and Neck Surgery, Shanghai Jiao Tong University School of Medicine
执行院长：
雷鸣 博士
研究员，博士生导师
国家杰出青年科学基金项目获得者
亚太蛋白质协会执行委员
中国生物物理协会副理事长
中国蛋白质协会副理事长
Science Bulletin杂志执行主编
Executive Director
LEI Ming / 雷鸣
Professor, Shanghai Jiao Tong University School of Medicine
The National Science Fund for Distinguished Young Scholars
Council Member, Asia Pacific Protein Association
Executive Editor, Science Bulletin
l 主要研究领域 / Research Fields
生殖医学与染色体研究
Reproductive Medicine & Chromatin
再生医学与发育研究
Regenerative Medicine & Development
肿瘤医学与表观遗传学研究
Cancer Medicine & Epigenetics
骨科医学与合成生物学研究
Osteopathic Medicine & Synthetic Biology
分子病理学与靶向药物
Molecular Pathology & Targeted Medicines
耳科/眼科医学与脑科学研究
Otology / Ophthalmology & Brain Science
l 科研团队 / Our Research Team
卞迁
职位：研究员，研究组长，博士生导师
研究方向：三维基因组结构、表观遗传学、衰老的生物学机制
Dr. BIAN Qian
Ph.D., Professor, Principal Investigator
Research Focus: 3D Genome Architecture, Epigenetics, Ageing
曹禹
职位：研究员，研究组长，博士生导师
研究方向：跨膜生物过程的分子机制；大分子药物开发
Dr. CAO Yu,
Professor, Principal Investigator
Research Focus: Metabolic process within membrane; drug discovery
华云峰
职位：研究员，研究组长，博士生导师
研究方向：大脑感官皮层三维超微结构
Dr. HUA Yunfeng
Professor, Principal Investigator
Research Focus: Study neuronal circuit ultrastructural basis of auditory brain function and diseases
黄晶
职位：研究员，研究组长，博士生导师
研究方向：肿瘤发生发展的表观遗传机制及靶向药物研发
Dr. HUANG Jing
Professor, Principal Investigator
Research Focus: Epigenetics and Cancer Biology
雷鸣
职位：研究员，研究组长，博士生导师
国家杰出青年科学基金项目获得者
研究方向：染色质结构与衰老分子机制
Dr. LEI Ming,
Executive Director, Professor, Principal Investigator
The National Science Fund for Distinguished Young Scholars
Research Focus: Telomere and chromosomal stability; chromatin structure and cancer
武健
职位：研究员，研究组长，博士生导师
研究方向：长非编码RNA-蛋白质复合物的结构与功能
Dr. WU Jian,
Professor, co-Principal Investigator
Research Focus: Structure and Function of Long non-coding RNA in Complex with Proteins
陈善双
职位：研究员，研究组长，博士生导师
研究方向：神经突触离子通道的结构与功能
Dr.CHEN Shanshuang
Professor, Principal Investigator
Research Focus：Structural and functional investigation of synaptic ion-channels
于士颜
职位：研究员，研究组长
研究方向：宿主-微生物相互作用，组织干细胞生物学
Dr.YU Shiyan
Professor, Principal Investigator
Research Focus：Host-Microbe Interactions, Tissue Stem Cell Biology
张燕捷
职位：主任医师，研究组长，博士生导师
研究方向：肿瘤靶向治疗与耐药机制的基础及临床研究
Dr.ZHANG Yanjie
Chief physician, Principal Investigator
Research Focus：Basic and clinical research on tumor targeted therapy and drug resistance mechanism
张家毓
职位：研究员，研究组长
研究方向：遗传性心脏病发展机制的生物学研究；诱导性干细胞及小鼠为基础的心肌力学理模型研究; 抗心肌衰老药物研究
Dr. CHANG Chia-Yu,
Professor, Principal Investigator
Research Focus: Genetic cardiomyopathy; hiPSC-CM; biomechanics of cardiomyocyte contraction; drug development
l 设施 / Our Facility
为支持科研发展，目前精准院已建成包括蛋白质平台、组学平台、电镜平台、生物成像平台、化学生物学平台、数据计算与分析平台等六大国际先进的科研设施平台。
To support the R&D activities, SHIPM has established six cutting-edge research facilities in the fields of Protein Engineering, Mass Spectroscopy, Electron Microscopy, Bio-imaging, Chemical Biology and Bioinformatics.
