Research published in Science from Shanghai First people’s Hospital

On March 9, a team of experts from Shanghai published a paper in the journal science, announcing the latest research results on improving type 2 diabetes by regulating intestinal microecology. Expert team found that through a variety of dietary fiber intake, can make the intestinal specific increase in the number of beneficial “flora” ecological function, promote insulin secretion and improve insulin sensitivity, and improve the type 2 diabetes. This paper was published by the professor Zhao Liping from Shanghai Jiao Tong University, professor zhao, professor Peng Yongde from Shanghai Jiao Tong University affiliated First People‘s Hospital endocrine metabolism department and Dr. Zhang Chenhong from Shanghai Jiao Tong University, state key laboratory of microbial metabolism. From the perspective of intestinal microecology, the team tried to find a new “target” to improve type 2 diabetes and its chronic complications.

In recent years, there have been studies have shown that intestinal flora in fat, sugar and lipid metabolism disorders play an important role in development and incidence of cardiovascular damage, these cells of the intestinal flora number 10 times that of the human body cell, coding millions of functional genes, known as the gut microbes group. These findings caused the panel’s thinking: now that gut bacteria can cause metabolic disease, then can by changing the structure of intestinal flora to treat metabolic disease, from “destroyer” as “builders”? Professor Peng Yongde said that this latest study is expected to provide a new direction for comprehensive prevention and treatment of type 2 diabetes mellitus, and help for a large number of people with pre-diabetes “reach mark”, in the form of nutritional intervention delay or reverse pre-diabetes progress. 

Shanghai First People‘s Hospital affiliated to Shanghai Jiao Tong University started in 2012 to support songjiang district health family planning system, and conducted community slow disease management program, established the community hypertension diabetes research queue management platform and multiple center in Sijing area. In Shanghai Jiao Tong University, professor Zhao and his team worked on early intestinal micro ecology research associated with obesity. 

On the basis of two sides of the digestive department professor Ceng Yue and director of endocrinology Peng Yongde, they made slow disease with micro ecological research program, to further explore the intestinal flora in type 2 diabetes the pathological and physiological mechanism of occurrence and development. The research is focused on the standard diabetes clinical comprehensive management, on the basis of the conventional treatment control group patients with diabetes diet health guidance, nutritional intervention in the treatment group patients consumption of whole grain cereal with large amounts of dietary fiber and prebiotics of feeding. 

The results showed that the increase in food in a large variety of dietary fiber, can be improved by changing the structure of intestinal flora in type 2 diabetes of insulin secretion and insulin sensitivity, which to a certain extent, delay the progress, the improvement of type 2 diabetes and symptoms, the direct reflection of glycosylated hemoglobin index down. 

After further study, the team also found a group of key functional bacteria closely related to the effects of nutritional interventions. This group plays a rolein functional bacteria in the form of “ecological function ”. It not only can improve insulin secretion, can also reduce indole by changing the intestinal environment and the production of hydrogen sulfide and other harmful metabolites, further enhance the recovery of metabolic disorder state. The team has identified 15 strains that are major contributors to high dietary fiber metabolism and have been shown to improve glucose metabolism in mice. 

Professor Peng Yongde pointed out that depends on slow disease management of hospital and community to build a queue, the team also will further establish the different stages of diabetes nutrition intervention plan, to adjust the structure and function of intestinal flora. The scheme maintains a healthy “microecology” of the intestine by selectively enriching the “beneficial bacteria” in the gut and reducing the “harmful bacteria”. At the same time, the mechanism of the changes in the structure and function of intestinal flora affecting the body’s physiology and metabolism is further analyzed, laying a foundation for the health management system targeting intestinal flora.