Sun Gang from Renji Hospital provides a new way of medicine for the prevention and treatment of premature delivery

Recently, Endocrine field top magazine “Endocrine Reviews, published online (IF: 15.745) a review paper by Professor Sun Gang and his teamfrom Renji Hospital affiliated Reproductive Medical Center, Shanghai key laboratory of assisted reproduction and eugenics, ” 11 beta HSD1 in human fetal membranes as a potential therapeutic target for preterm birth “. This paper summarizes more than 20 years of research work of Sun Gang‘s team, and proposes the possibility of fetal membrane glucocorticosteroid regeneration enzyme as a target for premature delivery. The first author is Dr. Wang Wangsheng and the corresponding author is Professor Sun Gang.

China has a preterm birth rate of 7%, with more than one million premature babies born every year. Preterm birth is not only the leading cause of perinatal neonatal death, but also the high rate of disability in surviving premature infants. Because the normal mechanism of human birth initiation has not been fully explained, there is still no effective means to prevent premature birth.

According to Sun Gang, fetal membranes are the most capable tissues in human fetal tissues to regenerate glucocorticoids, but their physiological and clinical significance is unclear. Since 1997, the year professor Sun Gang discovered that glucocorticoid recombinase 11 was abundant in fetal membranes, he has been interpreting the significance of abundant expression of this enzyme in fetal membranes. He led the team to find that the expression of fetal membrane 11 cahonia -HSD1 has a positive feedback mechanism that increases with pregnancy. By 11 beta HSD1 regeneration of glucocorticoid induced membranes in addition to promote the delivery of the hormone prostaglandin synthesis and promote the synthesis of uterine placenta activation of the hormone estrogen in childbirth start, also through the induction of apoptosis, degradation of collagen and inhibition of matrix protein crosslinking in extracellular matrix remodeling and membranes rupture of membranes. 

The results of this study explained the pregnancy fetal membrane regeneration of glucocorticoids in rupture of membranes and the physiological and clinical implications of birth start, also for membranes glucocorticoid regeneration loop development with targeted drugs provides a new train of thought for the prevention and control of preterm birth. , professor sun gang team about research in the role of corticosteroids in pregnancy, the key project of national natural Science fund, the national key basic research development plan, major national research and development plan and so on more than ten countries fund support, research achievements successively in Science Signaling (2), the J ClinEndocrinolMetab ”(11), journal of Endocrinology (10),“ Diabetes ”and“ JBC ”and“ J Endocrinology ”magazine published. Papersin his team were published four times by J ClinEndocrinolMetab magazine recommended for translational medicine, in 2015 the Science Signaling cover paper by the Science Signaling and the focal point of the Biology of Reproduction “review.In 2017 a paper from his group was also published in journal of Endocrinology.

This paper marks the team about regeneration glucocorticoid in membranes rupture of membranes and research achievements of birth start that received the affirmation of authoritative experts in this field. It alsoputs forward a new challengeon the glucocorticoid regeneration loop design of membranes for targeting drug prevention and treatment of premature birth.