王淑萍，博士，上海交通大学医学院附属仁济医院副研究员。上海市药学会药物分析专业委员会委员，上海市药学会生药学专业委员会委员。聚焦海洋天然环肽的高效发现体系构建、结构与功能研究。发表论文40余篇，其中第一或通讯作者论文18篇，包括 Org. Lett., J. Nat. Prod., Bioorg. Chem. 等。获授权中国发明专利4项。主持国家级项目5项，包括国家重点研发计划子任务3项、国家自然科学基金委面上项目和青年项目；作为核心成员（排名4/14）获自然资源部科技进步一等奖。

工作及教育经历

2025.01–至今 上海交通大学，医学院-仁济医院，副研究员

2013.07–2024.12 上海交通大学，医学院-仁济医院，助理研究员

2010.09–2013.07 中国人民解放军第二军医大学，天然药物化学，博士

2008.09–2010.07 中国人民解放军第二军医大学，天然药物化学，硕士

2003.09–2007.07 山东第一医科大学，药学，学士

科研项目

[1] 国家重点研发计划，2025YFC2817101，深海酶基因资源智能挖掘改造关键技术研发子任务，2025.05-2028.04，90万，在研，主持。

[2] 国家自然科学基金委员会, 面上项目, 82173730, 基于整合质谱策略的海绵环肽类新型RXRα拮抗剂的发现, 2022-01-01 至 2025-12-31, 55万元, 结题, 主持

[3] 国家自然科学基金委员会, 青年项目, 81402844, 利用活性筛选-质谱特征引导的双示踪法快速发现海绵环肽类抗肿瘤先导化合物, 2015-01-01 至 2017-12-31，23万元, 结题, 主持

[4]国家重点研发计划，2022YFC2804100，基于分子网络的深海天然 产物的发现与分析子任务，2022.11-2025.10，20万，结题，主持

[5] 国家重点研发计划，2018YFC0310900，深海动植物化学多样性的挖掘子任务，2018.08-2022.12，18万，结题，主持。

论文、专利与专著

[1] Ying Wu#; Zong-Mei Wu; Shuai-Shuai Zhang; Li-Yun Liu; Fan Sun; Wei-Hua Jiao; Shu-Ping Wang*; Hou-Wen Lin*. Axinellasins A−D, Immunosuppressive Cycloheptapeptide Diastereomers, Discovered via a Precursor Ion Scanning− Supercritical Fluid Chromatography Strategy from the Marine Sponge Axinella species, Organic Letters, 2022, 24: 934-938.

[2] Ying Wu; Hongze Liao; Li-Yun Liu; Fan Sun; Hai-Feng Chen; Wei-Hua Jiao; Hong-Rui Zhu; FanYang; Gang Huang; De-Quan Zeng; Mi Zhou; Shu-Ping Wang; Hou-Wen Lin. Phakefustatins A–C: Kynurenine-Bearing Cycloheptapeptides as RXRα Modulators from the Marine Sponge Phakellia fusca, Organic Letters, 2020, 22: 6703-6708.

[3] Xin-Li Lin, Shuai-Shuai Zhang, Si Zhang, Ying Wu, Zhao-Ze Xu, Xu Jing, Cui-Xian Zhang,* Hou-Wen Lin*, Shu-Ping Wang* Untargeted LC-MS Metabolomics-Driven Discovery of Unique Peptides Cyanogristatins A−E from Sponge-Associated Actinoalloteichus cyanogriseus LHW52806 and Anti-Inflammatory Activity Assessment. Journal of Natural Products, 2026, 89:151-160. (JCR Q1)

[4]  Shuai-Shuai Zhang, Ying Wu, Lei Li, Can Kong, Yuan-Yuan Zhang, Zong-Mei Wu, Shuai Liu, Si Zhang, Xin-Li Lin, Fan Sun, Wei-Hua Jiao*, Hou-Wen Lin*, Shu-Ping Wang* Neutral-loss scanning-guided discovery of cyanogriamides A−E: β-me-leu-bearing linear lipopeptides exhibiting cytotoxicity via PI3K/Akt/mTOR inhibition. Bioorganic Chemistry, 2025, 167, 109254 (JCR Q1).

[5] Dongdong Xie, Pei-Hai Li, Lu Zhang, Ruyi Shang, Jiaxin Li, Kechun Liu, Houwen Lin, Shuping Wang*, Weihua Jiao* Penicipenoids AG, antioxidant and anti-inflammatory cadinane sesquiterpenoids with rearranged carbon skeletons from the marine sponge symbiotic Penicillium sp. 5975, Chinese Journal of Natural Medicines, 2026, 1-9.

[6] Shuai-Shuai Zhang, Lei Li, Ying Wu, Zong-Mei Wu, Can Kong, Li-Li Hong, Si Zhang, Xin-Li Lin, Hou-Wen Lin*, Shu-Ping Wang*. LC-MS-Guided Isolation of Cyanogripeptides A−C, Cyclolipopeptides with β‑Methyl-Leucine Residues, from an Actinoalloteichus cyanogriseus LHW52806, Journal of Natural Products, 2023, 86, 1708-1714.

[7] Can Kong#, Ying Wu#, Hui-Min Zhao, Shuai-Shuai Zhang, Zong-Mei Wu, Xiao-Bin Li, Ke-Chun Liu, Hou-Wen Lin*, Shu-Ping Wang*. Phakellisins A-E, cyclopeptides from a marine sponge Phakellia sp. Guided by LC-MS. Bioorganic Chemistry, 2023, 139, 106699.

[8] Ying Wu#; Lei Liu#; Hai-Feng Chen; Wei-Hua Jiao; Fan Sun; Li-Yun Liu; Hong-Rui Zhu; Shu-Ping Wang*; Hou-Wen Lin*. Fuscasins A-D, Cycloheptapeptides from the Marine Sponge Phakellia fusca, Journal of Natural Products, 2019, 82, 4, 970-979.

[9] Ying Wu#, Zhao-ze Xu, Can Kong, Hui-Min Zhao, Shuai-Shuai Zhang, Zong-Mei Wu, Xiao-Bin Li, Ke-Chun Liu, Hou-Wen Lin*, Shu-Ping Wang*. Discovery of cycloheptapeptides phakefusins A-E from the marine sponge Phakellia fusca based on molecular networking, Phytochemistry, 2025,229, 114248.

[10]Shuai-Shuai Zhang, Zong-Mei Wu, Ying Wu, Ya-Jun Zeng, Yuan-Yuan Zhang, Xin-Li Lin, Si Zhang, Kai-Xuan Zhan, Hou-Wen Lin*, Shu-Ping Wang*. Discovery and configurations assignment of Ile/Leu-containing cyclic peptides with cytotoxic activity, Reniochpeptins A-D, from the marine sponge Reniochalina sp, Phytochemistry, 2025, 233; 114412.

[11] Bo Liu#; Shuping Wang#; Changhao Bian; Hongze Liao*; Hou-Wen Lin*. Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes, Chinese Journal of Chemistry, 2021, 39: 1905-1910.

[12] Shuping Wang; Peng Fu; Lei Liu; Lingling Wang; Chengcheng Peng; Weidong Zhang; Runhui Liu. Rapid discovery and identification of multiple absorbed chemical constituents and metabolites in rat cerebrospinal fluid after oral administration of Jitai tablets by a LC-MS based metabolomics approach, RSC Advances, 2016, 6: 32811-32822.

[13] Shuping Wang#, Chengcheng Peng#, Peng Jiang, Peng Fu, Jianfei Tao, Lin Han, Huimei Huang, Wanlin Chang, Le Li, Weidong Zhang*, Runhui Liu*. Simultaneous determination of seven bufadienolides in rat plasmaafter oral administration of Shexiang Baoxin Pill by liquidchromatography–electrospray ionization–tandem massspectrometry: Application to a pharmacokinetic study. J. Chromatogr. B, 2014, 967: 255-263.

[14] Shuping Wang#, Peng Fu#, Lei Liu#, Lingling Wang, Chengcheng Peng, Weidong Zhang*, Runhui Liu*. Simultaneous determination of fifteen constituents of jitai tablet using ultra high-performance liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry, Molecules, 2014，19 (9): 1635-1650.

[15] Shuping Wang#, Lei Liu#, Lingling Wang, Peng Jiang, Li Xiang, Weidong Zhang*, Runhui Liu*. Development and validation of ultra performance liquid chromatography-tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study. J. Pharm. Biomed. Anal, 2013, 72(18): 80-88.

[16] Shuping Wang#, Lei Liu#, Lingling Wang, Peng Jiang, Li Xiang, Weidong Zhang*, Runhui Liu*. Development and validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study J. Chromatogr. B, 2013, 912:75-84.

[17] Shuping Wang#, Lei Liu#, Lingling Wang, Yaohua Hu, Weidong Zhang*, Runhui Liu*. Structural characterization and identification of major constituents in Jitai tablets by high-performance liquid chromatography/diode-array detection coupled with electrospray ionization tandem mass spectrometry. Molecules, 2012,17(9): 10470-10493.

[18] Shuping Wang#, Lei Liu#, Lingling Wang, Weidong Zhang, Runhui Liu*. Structural characterization and identification of major constituents in Jitai tablets by high-performance liquid chromatography/diode-array detection coupled with electrospray ionization tandem mass spectrometry. Rapid Commun.Mass Spectrom, 2010, 24(11): 1641–1652.

申请或授权发明专利

[1] 林厚文; 王淑萍; 林昕历；张帅帅; 吴 莹；一种从蓝灰异壁放线菌中提取到的放线菌脂肽类化合物及其提取方法与应用，2025-11-21, 中国, 202511716405.X (申请)

[2] 林厚文; 王淑萍; 张帅帅; 吴莹; 俞佳蓝; 一种放线菌中线脂肽类化合物的提取方法与应用, 2025-11-14, 中国, 2025116697502 （申请专利）

[3] 林厚文; 王淑萍; 吴莹; 张帅帅; 海绵来源环肽类化合物及其制备方法与应用，2024-07-26, 中国, 202411010864.1 (申请)

[4] 林厚文; 王淑萍; 孔灿; 吴莹; 张帅帅; 赵慧敏; 海绵环肽类化合物及其制备方法与应用，2023-04-20, 中国, 202210414525.4 (申请)

[5] 林厚文; 王淑萍; 张帅帅；吴莹; 刘丽云; 一种放线菌环脂肽类化合物及其提取方法与应用，2023-07-04, 中国, 202310468224.4 (申请)

[6] 林厚文; 王淑萍; 吴宗梅; 吴莹; 孔灿; 从海绵中提取的环肽类化合物及其制备方法与应用，2022-12-06, 中国, ZL 2022 1 1555803.4 (授权)

[7] 林厚文; 王淑萍; 吴莹; 孔灿; 吴宗梅; 海绵环肽类化合物及其制备方法与应用, 2023-05-29, 中国, ZL 2022 1 0040993.X (授权)

[8] 林厚文; 王淑萍; 吴莹; 孙凡; 刘丽云; 肽类化合物及其制备方法与应用, 2021-12-03, 中国, ZL 2020 1 0557972.6 (授权)

[9] 林厚文; 王淑萍; 吴莹; 颜益珍; 孙凡; 刘丽云; 从棕色扁海绵中提取的环肽类化合物及其制备方法与用途, 2021-12-24, 中国, ZL 2019 1 0139942.0 (授权)

荣誉与奖励

[1] 王淑萍(4/14); 海洋生物活性物质高效挖掘技术体系的构建与应用, 自然资源科学技术奖励委员会,科技进步, 省部一等奖, 2023.04 (林厚文; 刘可春; 郭跃伟; 王淑萍; 孙 凡; 李晓彬; 靳 梦; 焦伟华; 杨 帆;易杨华; 王文风; 程跃谟; 蒋 毅; 蒋丽霞) (科研奖励)