上海交通大学医学院附属第六人民医院药剂科主任

上海交通大学医学院临床药学院副院长、主任药师、教授、博士生导师

中国药学会药学服务专委会副主任委员

中国药师协会药品临床评价专委会副主任委员

中华医学会临床药学专科分会委员

上海市医院协会临床药事管理专委会主任委员

上海市药学会医院药学专委会副主任委员

上海市医学会临床药学分会副主任委员

上海卒中学会临床药学分会副主任委员

工作及教育经历：

教育经历：

(1) 1983-09至1987-07,第二军医大学,药学,学士

(2) 1987-09至1990-07,第二军医大学,生药学,硕士

(3) 1990-09至1993-07,第二军医大学,生药学,博士

工作经历：

（1）1993-07 ~ 1996-07第二军医大学附属长征医院 主管药师

（2）1996-08 ~ 2001-07第二军医大学附属长征医院 副主任药师

（3）2001-08 ~ 2004-12第二军医大学附属长征医院 主任药师

（4）2005-1~至今 上海市第六人民医院药剂科 主任、主任药师、博士生导师

科研项目：

主持国家自然科学基金等科研项目20余项。

论文、专利与专著：

发表SCI论文70余篇，申请专利17项，授权国家发明/实用新型专利共5项。

1.Zhu W, Chen J, Zhao X, Ying X, Le C, Tang F, Qiu Y, Guo C, Xu R, Zhang J, The Influence of Pharmaceutical Care in Patients with Breast Cancer Receiving Adjuvant Endocrine Therapy, American Journal of Health Behavior, 2024, 48(1), 229-238.IF: 2.0 &Q3.

2.Yang Q, Zhu X, Huang P, Li C, Han L, Han Y, Gan R, Xin B, Tu Y, Zhou S, Yuan T, Hao J, Li C, Zhang L, Shi L, Guo C, BCKDK Modification Enhances the Anticancer Efficacy of CAR-T Cells by Reprogramming Branched Chain Amino Acid Metabolism, Molecular Therapy, 2024.IF: 12.4.

3.Lu J, Zhang J, Wang X, Yuan F, Xin B, Li J, Yang Q, Li X, Zhang J, Wang X, Fu J, Guo C, Dl-3-n-butylphthalide promotes microglial phagocytosis and inhibits microglial inflammation via regulating AGE-RAGE pathway in APP/PS1 mice, Brain Research Bulletin, 2024, 212, 110969.IF: 3.6&Q2.

4.Huang J, Chen J, Ma L, Zhu X, Wan L, Li X, Guo C, Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain, J Pain Res, 2024, 17, 1531-1545.IF: 2.7 &Q2.

5.Zhu X, Hao J, Zhang H, Chi M, Wang Y, Huang J, Xu R, Xincai Z, Xin B, Sun X, Zhang J, Zhou S, Cheng D, Yuan T, Ding J, Zheng S, Guo C, Yang Q, Oncometabolite D-2-hydroxyglutarate-dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia, Commun Biol, 2023, 6(1), 977.IF: 5.2.

6.Zhao X, Xu R, Wang Y, Zhou Y, Lu J, Zhu W, Qiu Y, Yang Q, Shen Z, Guo C, Zhang J, Adherence to Analgesic Drugs and its Associated Factors among Patients with Cancer Pain: A Crosssectional Study in China, Am J Health Behav, 2023, 47(1), 30-39.IF: 2.3.

7.Wang Y, Sun X, Yang Q, Guo C, Cucurbitacin IIb attenuates cancer cachexia induced skeletal muscle atrophy by regulating the IL-6/STAT3/FoxO signaling pathway, Phytother Res, 2023.IF: 7.2.

8.Sun X, Zhou L, Han Y, Yang Q, Li X, Xin B, Chi M, Wang Y, Guo C, Scutellarin Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Myocardial Fibrosis, Apoptosis and Autophagy in Rats, Chem Biodivers, 2023, 20(1), e202200450.IF: 2.9.

9.Kong QW, Yang J, Li D, Ding YW, Hu YJ, Xue XC, Shi MZ, Jiang B, Zhou YY, Zhang M, Hu JD, Guo C, Chen JJ, Han YL, Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo, J Ethnopharmacol, 2023, 300, 115728.IF: 5.4.

10.Chen L, Zhang H, Chi M, Wang Y, Zhu X, Han L, Xin B, Gan R, Tu Y, Sun X, Lu J, Li J, Huang J, Zhang J, Han Y, Guo C, Yang Q, Bckdk-Mediated Branch Chain Amino Acid Metabolism Reprogramming Contributes to Muscle Atrophy during Cancer Cachexia, Mol Nutr Food Res, 2023, e2300577.IF: 5.2.

11.Zhou L, Han Y, Yang Q, Xin B, Chi M, Huo Y, Guo C, Sun X, Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs, Toxicol In Vitro, 2022, 82, 105366.IF: 3.685.

12.Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S, A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy, Cell Metab, 2022, 34(4), 595-614.e514.IF: 31.373.

13.Yang# Q, Hao# J, Chi M, Wang Y, Li J, Huang J, Zhang J, Zhang M, Lu J, Zhou S, Yuan T, Shen Z, Zheng S, Guo* C, D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment, Mol Ther, 2022, 30(3), 1188-1200.IF: 11.454.

14.Yang Q, Hao J, Chi M, Wang Y, Xin B, Huang J, Lu J, Li J, Sun X, Li C, Huo Y, Zhang J, Han Y, Guo C, Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism, Oncoimmunology, 2022, 11(1), 2055703.IF: 8.11.

15.Chi MY, Zhang H, Wang YX, Sun XP, Yang* QJ, Guo* C, Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways, Oxid Med Cell Longev, 2022, 2022, 5694223.IF: 6.543.

16.Chen LL, Xia LY, Zhang JP, Wang Y, Chen JY, Guo C, Xu WH, Saikosaponin D alleviates cancer cachexia by directly inhibiting STAT3, Phytother Res, 2022(2022), 1-11.IF: 6.388.

17.Zhao# X, Xu# R, Wang Y, Zhu W, Hu H, Shen Z, Guo* C, Zhang* J, Impacts of Pharmacists-Managed Oncology Outpatient Clinic on Resolving Drug-Related Problems in Ambulatory Neoplasm Patients: A Prospective Study in China, Inquiry-The Journal of Health Care, 2021, 58, 1-8.IF: 1.73.

18.Zhang# J, Xu# R, Zhao X, Wang Y, W.H. Z, Misu X, Haiyan H, Lina T, Shen Z, C.* G, The effectiveness of an independent anti-neoplastic medication therapy management system in ambulatory cancer patients, Translational Cancer Research, 2021, 10(04), 1703-1711.IF: 1.241.

19.Zhang H, Chi M, Wang Y, Chen L, Sun X, Wan L, Yang* Q, Guo* C, Naringenin alleviates cisplatin induced muscle atrophy by regulating RIPK1/AMPK/NF-κB pathway, Journal of Functional Foods, 2021, 86, 104714.IF: 4.451.

20.Zhang H, Chi M, Chen L, Sun X, Wan L, Q.* Y, C.* G, Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway, Phytother Res, 2021, 35(8), 4363-4376.IF: 5.878.

21.Zhang H, Chi M, Chen L, Sun X, Yang Q, Wan L, C*. G, Study on possible synergistic anti-cancer cachexia effects of the main active compounds of Sophora flavescens Aiton, Traditional Medicine Research, 2021, 1-16.IF: ESCI.

22.Zhang H, Chen L, Sun X, Yang Q, Wan L, Guo* C, Matrine: A Promising Natural Product With Various Pharmacological Activities, Front Pharmacol, 2020, 11, 588.IF: 5.81.

23.Wan L, Lu J, Huang J, Huo Y, Jiang S, Guo* C, Association Between Peripheral Adiponectin and Lipids Levels and the Therapeutic Response to Donepezil Treatment in Han Chinese Patients With Alzheimer's Disease, Front Aging Neurosci, 2020, 12, 532386.IF: 5.75.

24.Q.# ZX, W.# DY, Chen JJ, Xiao X, Zhang W, Zhou L, Kong QW, Shi MZ, Yang J, Jiang B, C.* G, L.* HY, Xiaoaiping injection enhances paclitaxel efficacy in ovarian cancer via pregnane X receptor and its downstream molecules, J Ethnopharmacol, 2020, 261, 113067.IF: 4.36.

25.Lu J, Wang X, Wan L, Fu J, Huo Y, Zhao Y, Guo* C, Gene Polymorphisms Affecting the Pharmacokinetics and Pharmacodynamics of Donepezil Efficacy, Front Pharmacol, 2020, 11, 934.IF: 5.81.

26.Han L, Xu D, Xi Z, Wu M, Nik Nabil WN, Zhang J, Sui H, Fu W, Zhou H, Lao Y, Xu G, Guo C, Xu H, The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro, Front Pharmacol, 2020, 11(1882).IF: 5.81.

27.Chen# L, Yang# Q, Zhang H, Wan L, Xin B, Cao Y, Zhang J, Guo C, Cryptotanshinone prevents muscle wasting in CT26-induced cancer cachexia through inhibiting STAT3 signaling pathway, J Ethnopharmacol, 2020, 260, 113066.IF: 4.36.

28.Chen L, Xu W, Yang Q, Zhang H, Wan L, Xin B, Zhang J, Guo C, Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3, Pharmacological Research, 2020, 158, 104871.IF: 7.658.

荣誉与奖励：

以第一完成人获省部级科技进步奖二等奖、三等奖各1项