焦伟华，博士，研究员，博士生导师，国家优青。现就职于上海交通大学医学院附属仁济医院和临床药学院，主要从事海洋天然产物及微生物非核糖体肽合成酶工程化研究。2015.09-2017.09于澳大利亚昆士兰大学研究微生物抗菌肽的发现和作用机制，2022.01-2024.01在德国马普陆生微生物所进行细菌沉默非核糖体肽合成酶基因簇的活化与工程化研究。先后主持、参与了国家自然科学基金委青年基金、面上项目、国家重点研发计划、上海市科委等多项国家和省部级级项目，在国际权威期刊发表了80余篇研究论文，申请并获授权4项发明专利。先后入选上海市青年科技启明星、上海交通大学SMC-晨星青年学者、国家优青等人才项目。担任《中国化学快报》、《中国天然药物》和《沈阳药科大学学报》青年编委、中国药学会海洋药物专委会委员、中国海洋湖沼学会药学分会理事、上海药学会天然药物专委会委员等。
工作及教育经历：
教育经历：
2005.09-2010.07沈阳药科大学药学（天然药物化学）博士
2001.09-2005.07 沈阳药科大学 学士 药学专业
工作经历：
2010.08-2013.05 第二军医大学 助理研究员
2013.05-2016.11 上海交通大学医学院附属仁济医院助理研究员
2015.09-2017.09 澳大利亚昆士兰大学 博士后（合作导师：Robert J. Capon）
2016.12-2021.12 上海交通大学医学院附属仁济医院 副研究员，硕士生导师
2022.01-2024.01 德国马克斯普朗克陆生微生物研究所访问学者（合作导师：Helge B. Bode）
2022.01-至 今 上海交通大学医学院附属仁济医院 研究员，博士生导师
科研项目：
(1)科技部国家重点研发计划子课题肠道重要致病菌感染与宿主关键因子互作促进结直肠癌发生发展中的蛋白质机器研究（课题四：课题针对致病肠菌关键蛋白结构的药物设计和新药研发）（No. 2020YFA0509204），111万元，2020.11-2025.10，子课题 技术骨干（在研）
(2)国家自然科学基金委优秀青年科学基金 海洋药源分子的结构与功能(No.82022068)，120 万元，2021.01-2023.12，负责人（结题）
(3)上海交通大学医学院“双百人”计划海洋来源复杂结构代谢产物结构与功能(No. 20191811)，100 万元，2019.10.01-2022.09.30，负责人 （结题）
(4)上海市人力资源和社会保障局上海人才发展资金海绵及其共附生微生物中抗耐药菌活性化合物的高效发现(No. 2019096)，2019.10.01-2022.09.30，30万元，负责人（结题）
(5)科技部国家重点研发计划子课题深海药用动植物资源多样性及其可利用潜力的挖掘-子课题：海洋植物天然产物及先导化合物发现 (No. 2018YFC0310901), 30 万元；2018.08-2021.12，负责人（结题）
(6)国家自然科学基金应急管理项目海绵共附生Trichoderma属真菌中抗MRSA活性肽类化合物的发现及其构效关系研究 (No. 81741149), 20 万元；2018.01-2018.12，负责人（结题）
(7)国家自然科学基金面上项目海绵来源倍半萜醌类NF-kB抑制剂的发现及其抗肿瘤作用机制研究 (No. 41576130)，68万元；2016.01-2019.12，负责人（结题）
(8)上海交通大学“SMC-晨星”青年教师奖励计划海绵共生体中抗肿瘤新药先导化合物的发现(No. 20140309)，20 万元，2014.12-2017.12，负责人（结题）
(9)上海市科委科技支撑项目海绵共生放线菌Streptomyces sp. S10中新型抗骨髓瘤环缩肽的发现与成药性评价 (No.14431901300)，40 万元，2014.07-2017.09，负责人（结题）(10)上海市科委青年科技启明星项目 基于IKK-b/NF-kB通路的海绵新型抗肿瘤先导化合物的发现 (No. 14QA1402800)， 20 万元，2014.07-2016.06，负责人（结题）
(11)国家自然科学基金青年基金基于海绵化学防御策略的新型环境友好型海洋防污剂的发现（No.41106127），30万元，2012.01-2014.12，负责人（结题）
论文、专利与专著：
研究论文：
(1) Jia-Xin Li, Ru-Yi Shang, Dong-Dong Xie, Xiang-Chao Luo, Tian-Yong Hu, Bao-Hui Cheng,* Hou-Wen Lin,*Wei-Hua Jiao.* Arenarialins A-F, Anti-inflammatory Meroterpenoids with Rearranged Skeletons from the Marine SpongeDysidea arenaria.Journal of Natural Products,2024,87 (2), 396-403.
(2) Xianxian Miao, Lili Hong, Zhiran Ju, Hongyan Liu, Ruyi Shang, Peihai Li, Kechun Liu, Bin Cheng,Weihua Jiao,* Shihai Xu,* Houwen Lin.* Marchaetoglobins A−D: Four Cytochalasans with Proangiogenic Activity from the Marine-Sponge-Associated FungusChaetomium globosum 162105.ACS Omega 2024, 9, 22450−22458.
(3) Wei-Hua Jiao,*,#^ Jia-Xin Li,#^ Hong-Yan Liu,#^ Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen,* Bao-Hui Cheng,* Hou-Wen Lin.* Dysambiol, an Anti-inflammatory Secomeroterpenoid from aDysidea sp. Marine Sponge.Organic Letters,2023,25 (34), 6391−6395.
(4) Jia-Xin Li, Qi-Hang Xu, Ru-Yi Shang, Qian Liu, Xiang-Chao Luo, Hou-Wen Lin,*Wei-Hua Jiao.* Aspergetherins A-D, New Chlorinated Biphenyls with anti-MRSA Activity from the Marine Sponge Symbiotic FungusAspergillus terreus 164018.Chemistry & Biodiversity 2023,20(4), e202300010.
(5) Hong-Yan Liu, Mi Zhou, Ru-Yi Shang, Li-Li Hong, Guang-Hui Wang, Wen-Jing Tian,Wei-Hua Jiao*, Hai-Feng Chen*, Hou-Wen Lin*. Dysideanones F−G and Dysiherbols D−E, Unusual Sesquiterpene Quinones with Rearranged Skeletons from the Marine Sponge Dysidea avara.Chinese Journal of Natural Medicine 2022, 20 (2), 148-154.
(6) Ru-Yi Shang#, Jie Cui#, Jia-Xin Li, Xian-Xian Miao, Lu Zhang, Dong-Dong Xie, Liang Zhang, Hou-Wen Lin*,Wei-Hua Jiao*. Nigerin and ochracenes J-L, new sesquiterpenoids from the marine sponge symbiotic fungusAspergillus niger.Tetrahedron,2022,104, 132599.
(7) Jia-Bao Sun#, Li-Li Hong#, Ru-Yi Shang, Hong-Yan Liu, Lu Zhang, Li-Yun Liu, Lu Zhao, Wei Zhang, Fan Sun,Wei-Hua Jiao*, Hou-Wen Lin*. Dysiscalarones A-E, Scalarane Sesterterpenoids with Nitric Oxide Production Inhibitory Activity from Marine SpongeDysidea granulosa.Bioorganic Chemistry 2021,111, 104791.
(8) Lu Zhao, Li-Ling Zhang, Xian-Xian Miao, Jia-Xin Li, Hou-Wen Lin,*Wei-Hua Jiao*. New NF-кB Inhibitory Steroids from the Marine SpongeDysidea avara Collected from the South China Sea.Chemistry & Biodiversity 2021, 18 (10), e2100578.
(9) Jie Wang, Li Liu, Li-Li Hong, Kai-Xuan Zhan, Zheng-Jiang Lin,Wei-Hua Jiao*, Hou-Wen Lin*. New bisabolane-type phenolic sesquiterpenoids from the marine spongePlakortis simplex.Chinese Journal of Natural Medicines,2021,19 (8), 626-631.
(10) Li-Li Hong, Jie Wang, Li-Yun Liu, Fan Sun, Jia-Bao Sun, Xian-Xian Miao, Hong-Yan Liu, Kai-Xuan Zhan,Wei-Hua Jiao*, Hou-Wen Lin*, Hippobutenolides A and B, two new long-chain fatty acid esters from the marine spongeHippospongia lachne.Tetrahedron Letters 2021,84, 153437.
(11) Wei-Hua Jiao,*,# Qi-Hang Xu,# Guang-Bo Ge, Ru-Yi Shang, Hong-Rui Zhu, Hong-Yan Liu, Jie Cui, Fan Sun, Hou-Wen Lin.* Flavipesides A−C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic FungusAspergillus flavipes 164013.Organic Letters 2020, 22 (5), 1825-1829.
(12) Wei-Hua Jiao*, Qi-Hang Xu, Jie Cui, Ru-Yi Shang, Yun Zhang, Jia-Bao Sun, Qi Yang, Ke-Chun Liu, Hou-Wen Lin*. Spiroetherones A and B, Sesquiterpene Naphthoquinones as Angiogenesis Inhibitors from the Marine SpongeDysidea etheria.Organic Chemistry Frontiers 2020,7(2), 368-373.
(13) Yu-Han Gui, Li Liu, Wei Wu, Yun Zhang, Zhi-Li Jia, Yong-Ping Shi, Hao-Tian Kong, Ke-Chun Liu,Wei-Hua Jiao,* Hou-Wen Lin*. Discovery of Nitrogenous Sesquiterpene Quinone Derivatives from SpongeDysidea septosa with Anti-inflammatory Activity in vivo Zebrafish Model.Bioorganic Chemistry 2020, 94, 103435.
(14) Jie Cui, Ru-Yi Shang, Mei Sun, Yi-Xuan Li, Hong-Yan Liu, Hou-Wen Lin, Wei-Hua Jiao.* Trichodermaloids A-C, Cadinane Sesquiterpenes from a Marine Sponge SymbioticTrichoderma sp. SM16 Fungus.Chemistry & Biodiversity 2020, 17, e2000036.
(15) Mengxuan Chen, Yizhen Yan, Hengju Ge,Wei-Hua Jiao,* Zhizhen Zhang,* Hou-Wen Lin.* Pseudoceroximes A–E and Pseudocerolides A–E, Bromotyrosine Derivatives from aPseudoceratina sp. Marine Sponge Collected in the South China Sea.European Journal of Organic Chemistry 2020, 17, 2583-2591.
(16) Yong-Qi Tian, Bin-Bin Gu,Wei-Hua Jiao*, Hou-Wen Lin* Four homoverrucosane-type diterpenes from the marine spongeHalichondria sp.Tetrahedron 2020, 76 (50), 131697.
(17) Wei-Hua Jiao#, Angela Salim#, Zeinab Khalil#, Pradeep Dewapriya, Hou-Wen Lin, Mark Butler, Robert J. Capon*. Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-derived Fungus Trichoderma virens CMB-TN16.Journal of Natural Products 2019,82 (11), 3165-3175.
(18) Wei-Hua Jiao, Jing Li, Dan Wang, Meng-Meng Zhang, Li-Yun Liu, Fan Sun, Jing-Ya Li, Robert J. Capon*, Hou-Wen Lin*. Cinerols, Nitrogenous Meroterpenoids from the Marine SpongeDysidea cinerea.Journal of Natural Products 2019,82 (9), 2586-2593.
(19) Wei-Hua Jiao#, Jing Li#, Meng-Meng Zhang, Jie Cui, Yu-Han Gui, Yun Zhang, Jing-Ya Li, Ke-Chun Liu, Hou-Wen Lin*. Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates fromDysidea frondosa.Organic Letters 2019,21 (16), 6190-6193. (Supplementary Cover Art)
(20) Yu-Han Gui,Wei-Hua Jiao*, Mi Zhou, Yun Zhang, De-Quan Zeng, Hong-Rui Zhu, Ke-Chun Liu, Fan Sun, Hai-Feng Chen, Hou-Wen Lin*. Septosones A-C, in vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine SpongeDysidea septosa.Organic Letters 2019,21 (3), 767–770.
(21) Wei-Hua Jiao, Pradeep Dewapriya, Osama Mohamed, Zeinab G. Khalil, Angela A. Salim, Hou-Wen Lin, Robert J. Capon*. Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-derived FungusTrichodema virens CMB-TN16.Journal of Natural Products 2019,82 (1), 87−95.
(22) Wei-Hua Jiao, Bao-Hui Cheng, Guo-Dong Chen, Guo-Hua Shi, Jing Li, Tian-Yong Hu, Hou-Wen Lin*. Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine SpongeDysidea arenaria.Organic Letters 2018,20 (10), 3092-3095.
(23) Wei-Hua Jiao, Zeinab Khalil, Pradeep Dewapriya, Angela A. Salim, Hou-Wen Lin, Robert J. Capon*. Trichodermides A-E: Acyclic nonapeptides from the Australian termite nest-derived fungusTrichoderma virens CMB-TN16.Journal of Natural Products 2018,81 (4), 976−984.
(24) Jing Li#, Fan Yang#, Zhuo Wang#, Wei Wu, Li Liu, Shu-Ping Wang, Bin-Xin Zhao,Wei-Hua Jiao,* Shi-Hai Xu,* Hou-Wen Lin.* Unusual Anti-inflammatory Meroterpenoids from the Marine SpongeDactylospongia sp.Organic & Biomolecular Chemistry,2018,16 (36), 6773 – 6782.
(25) Jie Wang, Li-Yun Liu, Lei Liu, Kai-Xuan Zhan,Wei-Hua Jiao*, Hou-Wen Lin*. Pellynols M-O, Cytotoxic Polyacetylenic Alcohols from aNiphates sp. Marine Sponge.Tetrahedron 2018,74 (27), 3701-3706.
(26) Wei-Hua Jiao#, Wei Yuan#, Zhi-Yong Li, Jing Li, Lei Li, Jia-Bao Sun, Yu-Han Gui, Jie Wang, Bo-Ping Ye,* Hou-Wen Lin*. Anti-MRSA Actinomycins D1-D4 from the Marine Sponge-associatedStreptomyces sp. LHW52447.Tetrahedron 2018,74 (40), 5914-5919.
(27) Jing Li, Wei Wu, Fan Yang, Li Liu, Shu-Ping Wang,Wei-Hua Jiao*, Shi-Hai Xu*, Hou-Wen Lin*. Popolohuanones G-I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine SpongeDactylospongia elegans.Chemistry & Biodiversity 2018, e1800078.
(28) Jie Wang#, Feng-Rong Mu#,Wei-Hua Jiao*, Jian Huang, Li-Li Hong, Fan Yang, Ying Xu, Shu-Ping Wang, Fan Sun, Hou-Wen Lin*. Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from aHyrtios sp. Marine Sponge.Journal of Natural Products 2017,80 (9), 2509−2514.
(29) Wei-Hua Jiao#, Li-Li Hong#, Jia-Bao Sun#, Shu-Juan Piao, Guo-Dong Chen, Hai Deng, Shu-Piing Wang, Fan Yang, Hou-Wen Lin*. (±)-Hippolide J, a Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine SpongeHippospongia lachne.European Journal of Organic Chemistry2017,2017 (24), 3421-3426. (Very Important Paper)
(30) Wei-Hua Jiao#, Guo-Hua Shi#, Ting-Ting Xu#, Guo-Dong Chen, Bin-Bin Gu, Zhuo Wang, Shuang Peng, Shu-Ping Wang, Jia Li, Bing-Nan Han, Wei Zhang, Hou-Wen Lin* Dysiherbols A−C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from aDysidea sp. Marine Sponge.Journal of Natural Products2016,79 (2), 406-411.
(31) Wei-Hua Jiao#, Ting-Ting Xu#, Bin-Bin Gu#, Guo-Hua Shi, Yan Zhu, Fan Yang, Bing-Nan Han, Shu-Ping Wang, Yu-Shan Li*, Wei Zhang, Jia Li, Hou-Wen Lin*. Bioactive Sesquiterpene quinols and quinones from the marine spongeDysidea avara.RSC Advances 2015,5(106), 87730-87738.
(32) Wei-Hua Jiao#, Ting-Ting Xu#, Feng Zhao, Hao Gao, Guo-Hua Shi, Jie Wang, Li-Li Hong, Hao-Bing Yu, Yu-Shan Li*, Fan Yang, Hou-Wen Lin*.Dysifragilones A-C, Unusual Sesquiterpene Aminoquinones as Inhibitors of NO Production from the South China Sea SpongeDysidea fragilis.European Journal of Organic Chemistry2015 (5), 960-966.
(33) Wei-Hua Jiao#, Guo-Dong Chen#, Hao Gao*, Jing Li, Bin-Bin Gu, Ting-Ting Xu, Hao-Bing Yu, Guo-Hua Shi, Fan Yang, Xin-Sheng Yao*, Hou-Wen Lin*. (±)-Quassidines I and J, Two Pairs of Cytotoxic Bis-b-carboline Alkaloid Enantiomers fromPicrasma quassioides.Journal of Natural Products 2015,78 (1), 125-130.
(34) Wei-Hua Jiao, Ting-Ting Xu, Hao-Bing Yu, Guo-Dong Chen, Xiao-Jun Huang, Fan Yang, Yu-Shan Li, Bing-Nan Han, Xiao-Yan Liu*, Hou-Wen Lin*. Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea SpongeDysidea avara.Journal of Natural Products 2014,77 (2), 346-350.
(35) Hao-Bing Yu#, Fan Yang#, Fan Sun, Guo-Yi Ma, Jian-Hong Gan, Wen-Zhen Hu, Bing-Nan Han,Wei-Hua Jiao*, Hou-Wen Lin*.Cytotoxic Aaptamine Derivatives from the South China Sea SpongeAaptosaaptos.Journal of Natural Products 2014, 77 (9), 2124-2129.
(36) Wei-Hua Jiao#, Ting-Ting Xu#, Hao-Bing Yu, Feng-Rong Mu, Jia Li, Yu-Shan Li, Fan Yang, Bing-Nan Han, Hou-Wen Lin*. Dysidaminones A-M, Cytotoxic and NF-kB Inhibitory Sesquiterpene Aminoquinones from the South China Sea SpongeDysidea fragilis.RSC Advances 2014,4 (18), 9236-9246.
(37) Wei-Hua Jiao#, Jing Li#, Qian Liu, Ting-Ting Xu, Guo-Hua Shi, Hao-Bing Yu, Fan Yang, Bing-Nan Han, Min Li, Hou-Wen Lin*.Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea SpongeDysideasp.Molecules 2014, 19 (11), 18025-18032.
(38) Shu-Juan Piao#, Yun-Long Song#,Wei-Hua Jiao#, Fan Yang, Xiang-Fang Liu, Wan-Sheng Chen, Bing-Nan Han*, Hou-Wen Lin*. Hippolachnin A, a New Antifungal Polyketide from the South China Sea SpongeHippospongia lachne.Organic Letters 2013,15 (14), 3526-3529.
(39) Wei-Hua Jiao, Xiao-Jun Huang, Ji-Si Yang, Fan Yang, Shu-Juan Piao, Hao Gao, Jia Li, Wen-Cai Ye, Xin-Sheng Yao, Wang-Sheng, Chen, Hou-Wen, Lin*. Dysidavarones A-D, NewSesquiterpene Quinones from Marine SpongeDysidea avara.Organic Letters 2012,14 (1), 202-205.
(40) Wei-Hua Jiao, Hao Gao, Feng Zhao, Fei He, Guang-Xiong Zhou, Xin-Sheng Yao*. A New Sesquilignan and a New Sesterterpenoide from the Stems ofPicrasma quassioides Bennet. Chemistry & Biodiversity2011,8 (6), 1163-1169.
(41) Wei-Hua Jiao#, Hao Gao#, Feng Zhao,Hou-Wen Lin,Yu-Min Pan, Guang-Xiong Zhou, Xin-Sheng Yao*. Anti-inflammatory Alkaloids from the Stems ofPicrasma quassioides BENNET.Chemical & Pharmaceutical Bulletin2011,59(3), 359-364.
(42) Wei-Hua Jiao, Hao Gao, Chen-Yang Li,Feng Zhao,Ren-Wang Jiang, Ying Wang, Guang-Xiong Zhou, Xin-Sheng Yao*. Quassidines A–D, Bis-b-carboline Alkaloids from the Stems ofPicrasma quassioides. Journal of Natural Products2010,73 (2), 167-171.
(43) Wei-Hua Jiao, Hao Gao, Chen-Yang Li, Guang-Xiong Zhou, Susumu Kitanaka, Atsuko Ohmura, Xin-Sheng Yao*.b-carboline Alkaloids from the Stems ofPicrasma quassioides. Magnetic Resonance in Chemistry2010,48 (6), 490-495.
发明专利：
(1) 林厚文，焦伟华，徐启航 海绵共附生真菌来源黄柄碱及其制备方法与应用，申请号：201911368001.0，申请日：2019.12.26
(2) 焦伟华，林厚文海绵来源杂萜类化合物etherianones及其制备方法与应用，申请号：201911017363.5，申请日：2019.10.24 （授权号：CN112707805 B）
(3) 焦伟华，林厚文，李静，石国华海绵来源杂萜类化合物Dysiarenone及其制备方法与应用, 申请号：201810315628.9，申请日：2018.04.10 （授权号：CN109761948 B）
(4) 焦伟华，林厚文，袁薇，放线菌素类化合物actinomycins D1-D4及其制备方法与用途，专利号：ZL201810431002.4，申请日：2018.05.08 （授权号：CN 108715604 B）
(5) 焦伟华，林厚文，桂语晗，一种海绵来源杂萜类化合物及其制备方法与应用，申请号：201811510068.9，申请日：2018.12.11（授权号：CN 109704945 B）
(6) 林厚文，焦伟华 倍半萜醌类化合物Dysiherbols A及其制备方法和用途，申请号：201610083721.2，申请日：2016.05.04
(7) 林厚文，于豪冰，杨帆，焦伟华，西沙海绵中一种aaptamine生物碱类生物碱及其抗肿瘤用途，专利号：ZL201410181585.1，授权公开日：2016.05.04
(8) 林厚文，刘香芳，于豪冰，徐影，王茹萍，焦伟华，陈万生，一种链状聚酮类化合物及其用途，专利号：ZL201110105074.8，授权公开日：2013.11.06
(9) 林厚文，徐影，刘香芳，焦伟华，郎俊慧，于豪冰，朴淑娟，陈万生，二萜类化合物kalihinol T及其用途，申请号：201110420338.9，申请日：2011.12.15
荣誉与奖励：
(1) 国家自然科学基金委优秀青年科学基金获得者（2020）
(2)上海市人才发展资金计划（2019）
(3) 上海交通大学医学院“双百人”计划（2019）
(4) 上海交通大学SMC-晨星青年学者奖励计划（B类）（2015）
(5)上海市青年科技启明星计划（A 类）（2014）
(6) 辽宁省优秀博士学位论文（2012）
(7) 沈阳药科大学优秀博士学位论文（2011）
