基本信息：

张明亮研究员

干细胞与再生医学研究组

联系方式：上海市重庆南路280号7号楼

邮编：200025邮箱地址：mingliang.zhang@shsmu.edu.cn

研究方向：

基于干细胞的神经修复与再生

细胞重编程/转分化技术不但可以利用病人自身细胞为来源诱导产生疾病治疗所需细胞类型，也为体外疾病模拟、细胞命运转变调控机制研究和药物筛选提供了良好模型。本课题组将以体细胞重编程/（转）分化为模型，解析细胞命运维持和转变的调控机制；利用最新的细胞培养和基因编辑技术，探究器官发育/疾病发生的机理；通过化合物筛选等技术，研发针对神经系统发育/退行性疾病的药物疗法。课题组的长期研究目标是深入理解细胞命运决定机制，研发体外和体内定向诱导产生疾病治疗所需细胞的技术，推动干细胞治疗的临床转化。

个人简历：

2002年7月毕业于厦门大学，获学士学位；2009年7月毕业于中国科学院上海生物化学与细胞生物学研究所获博士学位；2010年9月至2016年11月分别在美国Scripps研究所和加州大学旧金山分校Gladstone研究所从事博士后研究，导师：丁胜教授

科研项目：

1上海高校特聘教授（东方学者）岗位计划上海市教委2018-01~2021-01 100万元课题负责人

2上海市浦江人才计划上海市科委2017-07~2019-06 20万元课题负责人

3国家自然科学基金委面上项目2018/1 – 2021/12 65万元课题负责人

代表性论文：

1.Liu Chang^#, Hu Xu^#, Li Yawen, Lu Wenjie, Li Wenlin, Cao Nan, Zhu Saiyong, Cheng Jinke, Ding Sheng*, andZhang Mingliang^#*. Conversion of mouse fibroblasts into oligodendrocyte progenitor-like cells through a chemical approach.Journal of Molecular Cell Biology.(2019) in press. doi: 10.1093/jmcb/mjy088 # co-first author, * co-corresponding author

2.Zhang Mingliang,Lin Yuan-Hung,Sun Yujiao Jennifer,Zhu Saiyong, Zheng Jiashun, Liu Kai, Cao Nan, Li Ke, Huang Yadong, and Ding Sheng. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.Cell Stem Cell(2016) 18 (5):653-667

3.Cao Nan, Huang Yu, Zheng Jiashun, Spencer C. Ian, Zhang Yu, Fu Ji-Dong, Nei Baoming, Xie Min,Zhang Mingliang, Wang Haixia, Ma Tianhua, Xu Tao, Shi Guilai, Srivastava Deepak and Ding Sheng. Conversion of Human Fibroblasts into Functional Cardiomyocytes by Small Molecules.Science(2016) 352 (6290):1216-1220

4.Zhu Saiyong, Russ Holger A., Wang Xiaojing,Zhang Mingliang, Ma Tianhua, Xu Tao, Tang Shibing, Hebrok Matthias, and Ding Sheng. Human pancreatic beta-like cells converted from fibroblasts.Nature Communications(2016) 7:10080

5.Xie Fei, Gong Kerui, Li Ke,Zhang Mingliang, Chang Judy C., Jiang Shizhong, Ye Lin, Wang Jiaming, Tan Yuting,and Kan YuetWai. Reversible immortalization enables seamless transdifferentiation of primary fibroblasts into other lineage cells.Stem Cells & Development(2016) 25 (16):1243-1248

6.Zhu Saiyong, Ambasudhan Rajesh, Sun Woong, Kim Hyun Jung, Talantova Maria, Wang Xiaojing,Zhang Mingliang, Zhang Yu, Laurent Timothy, Parker James, Kim Han-Seop, Zaremba Jeffrey D, Saleem Sofiyan, Sanz-Blasco Sara, Masliah Eliezer, McKercher Scott R, Cho Yee Sook, Lipton Stuart A, Kim Janghwan and Ding Sheng. Small Molecules Enable Oct4-Mediated Direct Reprogramming into Expandable Human Neural Stem Cells.Cell Research(2014) 24 (1):126-129

7.Xu Tao^#,Zhang Mingliang^#,Laurent Timothy, Xie Min, and Ding Sheng.Concise review: Chemical Approaches for Modulating Lineage-Specific Stem Cells and Progenitors.Stem Cells Translational Medicine(2013) 2 (5): 355-361.^#co-first author

8.Tong Xiajing, Li Qianjin, DuanYimin, Liu Ningning, Zhang Mingliang and Zhou Jinqiu. Est1 protects telomeres and inhibits subtelomeric Y’-element recombination.Molecular & Cellular Biology(2011) 31(6):1263-1274

9.Zhang Mingliang#, Tong Xiajing#, Fu Xiaohong, Zhou BO, Wang Jianyong, Liao Xinhua，Li Qianjin, Shen Ning, Ding Jianping and Zhou Jinqiu. Yeast telomerase subunit Est1p has guanine-quadruplex promoting activity that is required for telomere elongation.Nature Structural & Molecular Biology(2010) 17 (2):202-209.# co-first author

10.Liao Xinhua,Zhang Mingliang, Yang Cuiping, Xu Luxia, Zhou Jinqiu. Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast.Biochemical Journal(2005) 390 (Pt 1):169-176

学术专著章节：

Zhang Mingliang^#, Li Ke^#, Xie Min, and Ding Sheng. Chemical Approaches to Controlling Cell Fate. inPrinciples of Developmental Genetics, 2nd Edition, Moody S., (2014) Academic Press. pp59-76.^#co-first author

专利与技术许可：

Zhang Mingliang, and Ding Sheng. Chemical reprogramming to generate neuronal cells，PCT/US2016/045290, WO/2017/027280

荣誉与奖励：

1.2018年获上海高校特聘教授（东方学者）计划支持

2. 2017年获上海市浦江人才计划支持