个人简介：2021年毕业于中国科学院大学上海营养与健康研究所，获得医学博士学位，专业方向为免疫学；2021-2023年在上海交通大学医学院公共卫生学院从事博士后研究工作；2023.12-至今进入上海交通大学医学院公共卫生学院工作。主要从事慢性肝脏疾病及相关肿瘤的防治研究。通过深入研究遗传因素与环境因素如何影响肝脏组织稳态，进而影响肝癌发生发展及药物应答，从而寻找有效的化学预防和免疫预防的靶点。近年来，研究成果以第一/共同第一作者的身份发表在Nature Communications、Journal For Immunotherapy of cancer、Clinical and Translational Medicine等国际一流杂志，共发表SCI研究论文12余篇，综述1篇。
主持项目：中国博士后科学基金站中特别资助，中国博士后科学基金面上资助。
奖励荣誉：2020年获博士研究生国家奖学金，2021年获上海市优秀毕业生，2021年获上海市超级博士后资助，2021年获上海交通大学医学院博后激励计划资助。
研究领域：慢性肝脏疾病及相关肿瘤的防治研究
1、围绕“病因发现-功能及靶点研究-靶向干预”的核心研究策略，通过深入研究相关病因如何调控肝脏组织稳态及肝癌病变进而影响肝癌发生发展及药物应答，发现治疗的新靶点。
2、探索主动健康生活方式（如膳食营养、情绪压力、运动等）在慢性肝脏疾病及相关肿瘤的防治中的作用及机制研究。
代表性成果：
Ø Y. Yang, M. Sun, W. Yao, F. Wang, X. Li, W. Wang, J. Li, Z. Gao, L. Qiu, R. You, C. Yang, Q. Ba, H. Wang, Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib. Journal for ImmunoTherapy of Cancer. 2020;8: e000317. (第一作者，IF=13.751)
Ø Y. Yang, M. Sun, W. Li, C. Liu, Z. Jiang, P. Gu, J. Li, W. Wang, R. You, Q. Ba, X. Li, H. Wang. Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis. Clinical and Translational Medicine. 2021;11: e410. (第一作者，IF=11.492)
Ø Y.Yang, Y. Lu, T. Pei, B. Guo, J. Li, H. Wang, Q. Ba. Compound kushen injection in cancer treatments: Efficacy, active ingredients, and mechanisms. Pharmacological Research - Modern Chinese Medicine. 2022; 3:100108. (第一作者)
Ø C. Liu, Y. Yang, C. Chen, L. Li, J. Li, X. Wang, Q. Chu, L. Qiu, Q. Ba, X. Li, H. Wang. Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice. Nature Communications, 2021, 12:5725. (共同第一作者，IF=17.694)
Ø M. Sun, P. Gu, Y. Yang, L. Yu, Z. Jiang, J. Li, Y. Chen, Q. Ba, H. Wang. Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis. Journal for ImmunoTherapy of Cancer. 2021; 9:e002508. (共同第一作者，IF=13.751)
Ø Pu Yang, Jie Pan, Haibo Wang, Xu Xiaohan, Xu Zeling, Xuenhong Chen, Yang Yang, Hongzhe Sun, Meng Li, Olivier Habimana. Structural, metagenomic and metabolic shifts in multispecies freshwater biofilm models exposed to silver nanoparticles. Journal of Environmental Chemical Engineering, 2023, 11(1): 109162.
Ø Bai PY, Chen SQ, Jia DL, Pan LH, Liu CB, Liu J, Luo W, Yang Y, Sun MY, Wan NF, Rong WW, Sun AJ, Ge JB. Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival. Science Advances. 2022 Apr 29;8(17): eabm3436.
Ø Li Y, Zhang L, Ren P, Yang Y, Li S, Qin X, Zhang M, Zhou M, Liu W. Qing-Xue-Xiao-Zhi formula attenuates atherosclerosis by inhibiting macrophage lipid accumulation and inflammatory response via TLR4/MyD88/NF-κB pathway regulation. Phytomedicine. 2021 Dec; 93:153812.
Ø Gu P, Sun M, Li L, Yang Y, Jiang Z, Ge Y, Wang W, Mu W, Wang H. Breast Tumor-Derived Exosomal MicroRNA-200b-3p Promotes Specific Organ Metastasis Through Regulating CCL2 Expression in Lung Epithelial Cells. Frontiers in Cell and Developmental Biology. 2021 Jun 24; 9:657158.
Ø Pu Y, Pan J, Yao Y, Ngan WY, Yang Y, Li M, Habimana O. Ecotoxicological effects of erythromycin on a multispecies biofilm model, revealed by metagenomic and metabolomic approaches. Environmental Pollution. 2021 May 1; 276:116737.
Ø Jiang Z, Mu W, Yang Y, Sun M, Liu Y, Gao Z, Li J, Gu P, Wang H, Lu Y, Ba Q, Wang H. Cadmium exacerbates dextran sulfate sodium-induced chronic colitis and impairs intestinal barrier. Science of The Total Environment. 2020 Nov 20; 744:140844.
Ø Huang C, Sun M, Yang Y, Wang F, Ma X, Li J, Wang Y, Ding Q, Ying H, Song H, Wu Y, Jiang Y, Jia X, Ba Q, Wang H. Titanium dioxide nanoparticles prime a specific activation state of macrophages. Nanotoxicology. 2017 Aug; 11(6):737-750.
