食品安全与毒理学系

程薇/ 职称:助理研究员

学历学位:博士 研究生

Email: wcheng@shsmu.edu.cn

个人简介:

程薇,女,2017年毕业于上海交通大学,获医学博士学位。现就职于上海交通大学医学院公共卫生学院食品安全与毒理学系。中国毒理学会认证毒理学家。主持国家级、省部级科研项目3项,申报发明专利9项(已授权2项),参与2项团体标准编制。以第一作者/通讯作者在Environ IntSci Total EnvironToxicol Appl PharmacolCell Biol Toxicol等环境与健康、毒理学领域的权威期刊发表SCI论文13篇(累计影响因子大于100)。


研究方向:

1. 毒性测试替代方法与新途径技术方法

2. 基于类器官、器官芯片的新污染物毒性筛选和靶器官毒性机制

3. 微塑料的危害识别和风险评估;


代表性研究成果(近三年)

1. Cheng W*, Zhou Y, Chen H, Wu Q, Li Y, Wang H, Feng Y, Wang Y*. The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids. Sci Total Environ. 2023. (just accepted)

2. Zhou Y, Wu Q, Li Y, Feng Y, Wang Y*, Cheng W*. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids. Environ Int, 2023, 179:108171.

3. Cheng W*, Zhou Y, Xie Y, Li Y, Zhou R, Wang H, Feng Y, Wang Y*. Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: the hepatotoxicity and lipid accumulation. Sci Total Environ, 2023, 854:158585.

4. Xie Y, Li Y, Feng Y, Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit. Environ Int, 2022, 162:107151.

5. Cheng W*, Li X, Zhou Y, Yu H, Xie Y, Wang H, Li Y, Feng Y, Wang Y*. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Sci Total Environ, 2022, 806 (Pt 1): 150328.

6. Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol, 2022, 38:409-426.

7. Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes. Toxicol Appl Pharmacol.2020, 388:114850.

8. Cheng W, Yang S, Liang F, Zhou R, Li Y, Feng Y, Wang Y*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway. Food Chem Toxicol. 2019, 127:1-10.

9. Li X, Cheng W*, Yang S, Liang F, Wang H, Feng Y, Wang Y*. Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett, 2022, 355:1-18.

10. Wang L#, Cheng W#, Zhu J#, Li W*, Li D, Fu Q, Mo X, Yang X, Zhao W, Ren M, Ren J, Zhang K*. Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: evaluations in vitro and in vivo. Colloids Surf B Biointerfaces, 2022, 209: 112218.

11. Zhou R, Cheng W, Feng Y, Wang W, Liang F, Luo F, Yang S, Wang Y*. Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments. Environ Toxicol Pharmacol, 2020, 80: 103434.

12. Yang S, Cheng W, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/eNOS pathway. Toxicology, 2020,432:152380.

13. Yu H, Guo H, Feng Y, Cheng W, Wang Y*. Exosomes from PM2.5-treated Human Bronchial Epithelial Cells Increase Lung Cancer Metastatic Potential. Biomed Environ Sci, 2022, 35(6):473-484.

14. Guo H#, Yu H#, Feng Y, Cheng W, Li Y, Wang Y*. The role of estrogen receptor β in fine particulate matter (PM 2.5) organic extract-induced pulmonary inflammation in female and male mice. Environ Sci Pollut Res Int, 2022, 29:60922-60932.

15. Zhou R, Xia M, Zhang L, Cheng W, Yan J, Sun Y, Wang Y*, Jiang H*. Individual and combined effects of BPA, BPS and BPAF on the cardiomyocyte differentiation of embryonic stem cells. Ecotoxicol Environ Saf, 2021,220:112366.

16. Zhou R, Cheng W, Feng Y, Wang W, Liang F, Luo F, Yang S, Wang Y*. Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments. Environ Toxicol Pharmacol, 2020, 80: 103434.