环境与健康系

谢和辉/ 职称：研究员

学历学位：博士 研究生

Email: xhhtom@263.net

谢和辉，男，教授。1995年上海医科大学（复旦大学上海医学院）毕业，获学士学位。2003年第二军医大学博士研究生毕业，获博士学位。2006-2008年在美国密歇根州立大学药理学与毒理学系做访问学者。2008年至今相继担任第二军医大学药理学教研室副教授、上海交通大学公共卫生学院研究员。2013年至今，兼任中南大学血管与转化医学中心“升华学者”特聘教授、博士生导师。曾主持国家自然科学基金项目4项，是973计划子课题、教育部创新团队骨干。在《Stroke》、《Hypertension》《EBionedicine》等杂志发表SCI收录文章40余篇。曾获国家自然科学二等奖、上海市自然科学二等奖、第十届中国药理学会Servier奖等。是国际杂志《Front Pharmacol》的Review Editor，《Arterioscler Thromb Vasc Biol》等国际杂志审稿人，国家自然科学基金面上项目通讯评议专家。从事心脑血管药理学和毒理学研究。

主要研究方向

  1. 环境因素对心脑血管疾病的影响及其机制

  2. 脑卒中与内皮祖细胞

主要研究课题

  1. 国家自然科学基金（81370253）：二氯乙酸钠改善糖尿病小鼠内皮祖细胞功能及其在脑缺血损伤治疗中的应用。80万。2014.01-2017.12。课题负责人。

  2. 973计划子课题（2014CB542403）：线粒体应激在糖尿病继发血管内皮细胞损伤和修复中的作用及干预措施。500万。2014.01-2018.12。骨干。

  3. 国家自然科学基金（81170115）：MnSOD缺陷引起的内皮祖细胞功能障碍加重小鼠脑缺血损伤。60万。2012.01-2015.12。课题负责人。

  4. 国家自然科学基金（30971158）：低肾素性高血压小鼠内皮祖细胞功能失常的TSP-1机制。35万。2010.01-2012.12。课题负责人。

  5. 国家自然科学基金（30700307）：氧化应激与去氧皮质酮/盐高血压小鼠内皮祖细胞数量减少。22万。2008.01-2010.12。课题负责人。

  6. 教育部创新团队：脑卒中发生和防治的基础研究。300万。2010.01-2012.12。骨干。

主要研究成果

  1. Xie HH, Miao CY, and Su DF. Importance of blood pressure variability in the organ protection in spontaneously hypertensive rats treated with combination of nitredipine and atenolol. Acta Pharmacol Sin 2002; 23: 1199-204.

  2. Miao CY, Xie HH, Wang JJ, Su DF. Candesartan inhibits sinoaortic denervation -induced cardiovascular hypertrophy in rats. Acta Pharmacol Sin 2002; 23: 713-20.

  3. Lu ZA, Xie HH, Xu LP, Yin AF, Miao CY, and Su DF. Restoration of arterial baroreflex function contributes to organ protection in spontaneously hypertensive rats treated with long-term hydrochlothiazide mixture. Clin Exp Pharmacol physiol 2003; 30: 49-54.

  4. Xie HH, Miao CY, Liu JG, and Su DF. Effects of Long-Term Treatment with Candesartan on Organ Damages in Sinoaortic Denervated Rats. J Cardiovasc Pharmacol 2003; 41: 325-31.

  5. Miao CY, Xie HH, Yu H, Chu ZX, Su DF. Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats. Clin Exp Pharmacol physiol 2003; 30: 189-93.

  6. Zhang C, Chen H, Xie HH, Shu H, Yuan WJ, Su DF. Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. J Hypertens. 2003; 21: 2141-8.

  7. Cai GJ, Li L, Xie HH, Xu JJ, Miao CY, Su DF. Morphological evidence of reinnervation of the baroreceptive regions in sinoaortic-denervated rats. Clin Exp Pharmacol Physiol. 2003; 30: 925-9.

  8. Su DF, Xu LP, Miao CY, Xie HH, Shen FM, Jiang YY. Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats. Acta Pharmacol Sin. 2004; 25: 148-51.

  9. Zhang C, Xie HH, Lu ZA, Zhu MJ, Su DF. Inhibition of inflammation contributes to organ protection of atenolol in sinoaortic-denervated rats. J Cardiovasc Pharmacol. 2004; 43: 663-8.

  10. Miao CY, Xu LP, Liu JG, Xie HH, Yuan WJ, Su DF. Frequent ventricular premature beats increase blood pressure variability in rats. Acta Pharmacol Sin. 2004; 25: 545-53.

  11. Shen FM, Guan YF, Xie HH, Su DF. Arterial baroreflex function determines the survival time in lipopolysaccharide-induced shock in rats. Shock. 2004; 21: 556-60.

  12. Miao CY, Cai GJ, Tao X, Xie HH, Su DF. Greater hypertrophy in right than left ventricles is associated with pulmonary vasculopathy in sinoaortic-denervated wistar-kyoto rats. Clin Exp Pharmacol Physiol. 2004; 31: 450-5.

  13. Xie HH, Miao CY, Jiang YY, Su DF. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens 2005; 23: 193-201.

  14. Xie HH, Shen FM, Cao YB, Li HL, Su DF. Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats. Clin Sci (Lond). 2005; 108: 547-52.

  15. Cai GJ, Miao CY, Xie HH, Lu LH, Su DF. Arterial baroreflex dysfunction promotes atherosclerosis in rats. Atherosclerosis. 2005; 183(1): 41-7.

  16. Wang DS, Xie HH, Shen FM, Cai GJ, Su DF. Blood pressure variability, cardiac baroreflex sensitivity, and end organ damage in experimentally hypertensive rats. Clin Exp Pharmacol Physiol 2005; 32: 545-52.

  17. Xie HH, Shen FM, Miao CY, Su DF. Blood pressure, baroreflex sensitivity and end organ damage in hybrid offspring of SHR and SD rats. Acta Pharmacol Sin 2005; 26: 1049-56.

  18. Shen FM, Xie HH (co-first author), Ling G, Xu LP, SU DF. Synergism of atenolol and amlodipine on lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin 2005; 26: 1303-8.

  19. Lu LH, Xie HH, Cai GJ, Shen FM, Su DF. Diminished responses to nifedipine imply severe end-organ damage in spontaneously hypertensive rats. J Cardiovasc Parmacolol 2005; 46: 836-41.

  20. Xie HH, Chen YY, Miao CY, Shen FM, Su DF. Effects of long-term treatment with candesartan on hemodynamics and organ damage in spontaneously hypertensive rats. Cardiovasc Drugs Ther 2005; 19: 391-7.

  21. Shen FM, Zhang SH, Xie HH, Su DF. Early structural changes of aortic wall in sinoaortic denervated rats. Clin Exp Pharmacol Physiol 2006; 33: 358-63.

  22. Miao CY, Xie HH, Zhan LS, Su DF. Blood pressure variability is more important than blood pressure level in determination of end-organ damage in rats. J Hypertens 2006; 24: 1137-46.

  23. Gu XW, Xie HH, Wang J, Shen FM, Su DF. Arterial baroreflex is not involved in salt preference in rats. Clin Exp Pharmacol Physiol 2006; 33: 607-11.

  24. Xie HH, Shen FM, Zhang XF, Jiang YY, Su DF. Blood pressure variability, baroreflex sensitivity and organ damage in spontaneously hypertensive rats treated with various antihypertensive drugs. Eur J Pharmacol 2006; 543: 77-82.

  25. Han P, Chu ZX, Shen FM, Xie HH, Su DF. Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. Acta Pharmacol Sin. 2006; 27: 1575-9.

  26. Li M, Wang J, Xie HH, Shen FM, Su DF. The susceptibility of ventricular arrhythmia to aconitine in conscious Lyon hypertensive rats. Acta Pharmacol Sin. 2007; 28: 211-5.

  27. Xie HH, Shen FM, Xu LP, Han P, Miao CY, Su DF. Reduction of blood pressure variability by combination therapy in spontaneously hypertensive rats. J Hypertens 2007; 25: 2334–44.

  28. Xie HH, Zhang XF, Chen YY, Shen FM, Su DF. Synergism of Hydrochlorothiazide and Nifedipine on Blood Pressure Variability Reduction and Organ Protection in Spontaneously Hypertensive Rats. Hypertens Res 2008; 31: 685–691.

  29. Han P, Shen FM, Xie HH, Chen YY, Miao cy, Mehta JL, Sassard J, Su DF. The combination of atenolol and amlodipine is better than their monotherapy for preventing end-organ damage in different types of hypertension in rats. J Cell Mol Med 2009; 13: 726-734.

  30. Xie HH, Zhou S, Chen D, Channon KM, Su DF, Chen AF. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension 2010;56:1137-1144

  31. Yu YS, Xie HH, Li L, Song SW, Han P, Cai GJ, Su DF. Effects of low-dose ketanserin on atherosclerosis in rats and rabbits. Can J Physiol Pharmacol. 2010; 88: 1054-1060

  32. Ni M, Yang ZW, Li DJ, Li Q, Zhang SH, Su DF, Xie HH (Co-corresponding author), Shen FM. A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure overload rat model. J Pharmacol Sci 2010; 114: 311-319

  33. Shang W, Han P, Yang CB, Gu XW, Xu LP, Fu ST, Su DF, Xie HH (Corresponding author). Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats. Acta Pharmacol Sin. 2011; 32: 1109-1115.

  34. Ma J, Peng C, Guo W, Dong YF, Dong XH, Sun X, Xie HH (Corresponding author). A modified model of middle cerebral artery electrocoagulation in mice. CNS Neurosci Ther 2012; 18: 796-798.

  35. Liu F, Chen DD, Sun X, Xie HH, Yuan H, Jia W, Chen AF. Hydrogen Sulfide Improves Wound Healing via Restoration of Endothelial Progenitor Cell Functions and Activation of Angiopoietin-1 in Type 2 Diabetes. Diabetes. 2014; 63: 1763-78.

  36. Tie L, Chen LY, Chen DD, Xie HH, Channon KM, Chen AF. GTP Cyclohydrolase I Prevents Diabetic Impaired Endothelial Progenitor Cells and Wound Healing by Suppressing Oxidative Stress/Thrombospondin-1. Am J Physiol Endocrinol Metab 2014; 306: E1120-31.

  37. Dong XH, Sun X, Jiang GJ, Chen AF, Xie HH (Corresponding author). Dietary intake of sugar substitutes aggravates cerebral ischemic injury and impairs endothelial progenitor cells in mice. Stroke 2015; 46: 1714-18.

  38. Jiang Y, Wang LP, Dong XH, Cai J, Jiang GJ, Zhang C, Xie HH. Trace amounts of copper in drinking water aggravate cerebral ischemic injury via impairing endothelial progenitor cells in mice. CNS Neurosci Ther 2015; 21: 677-80.

  39. Wang LP, Jiang Y, Yang H, Peng C, Zhang C, Tao X,Xie HH (Corresponding author).Combination therapy of nifedipine and sulphonylureas exerts a mutual antagonistic effect on the endothelial cell dysfunction induced by hyperglycaemia linked to vascular disease. Cell Physiol Biochem 2016; 38: 2337-2347.

  40. Xin B, Liu CL, Yang H, Peng C, Dong XH, Zhang C, Chen AF,Xie HH (Corresponding author).Prolonged fasting improves endothelial progenitor cell-mediated ischemic angiogenesis in mice. Cell Physiol Biochem 2016; 40: 693-706.

  41. Dong XH, Peng C, Zhang YY, Tao YL, Tao X, Zhang C, Chen AF,Xie HH (Corresponding author). Chronic exposure to subtherapeutic antibiotics aggravates ischemic stroke outcome in mice. EBiomedicine 2017; 24: 116-126.

  42. Peng C, Wang LP, Tao X, Dong XH, Xu CF, Jiang Y, Liu CL, Ma HF, Zhang C, Chen AF,Xie HH (Corresponding author). Preventive cold acclimation augments the reparative function of endothelial progenitor cells in mice. Cell Physiol Biochem 2018; 45: 175-191.

科技奖励

  1. 血压波动性与器官损伤的研究，国家自然科学二等奖，中华人民共和国国务院，2009年12月。获得者：苏定冯，缪朝玉，沈甫明，谢和辉，刘建国。

  2. 动脉压力感受性反射与心血管疾病，上海市自然科学二等奖，上海市人民政府，2006年11月。获得者：苏定冯，缪朝玉，沈甫明，谢和辉，刘建国。

  3. 第十届中国药理学会Servier奖，中国药理学会，2006年11月。获得者：谢和辉。