上海精准医学研究院系列学术报告
2018-04-11浏览(511来源:基础医学院 

  主题:Structural Biology of RNA-mediated Gene Regulation  

  主讲嘉宾:Dr. Dinshaw J. Patel

       Member and Abby Rockefeller Mauzé Chair in Experimental Therapeutics,

       Structural Biology Program,Memorial Sloan-Kettering Cancer Center

       Member, National Academy of Sciences, 2009

       Member, American Academy of Arts and Sciences, 2014             

   

  报告摘要:

  The role of RNA in information transfer and catalysis highlights its dual functionalities. Much of our effort in this area has focused on metabolite-sensing riboswitches and nucleolytic self-cleaving ribozymes on the one hand, and on CRISP-Cas systems on the other. The lecture will provide a few examples of principles underlying metabolite recognition by riboswitches, our studies on catalytic mechanisms adopted by nucleolytic ribozymes and recent x-ray and cryoEM studies on ternary complexes of Cas nucleases and multisubunit Cascades with bound crRNA and target DNA, and the impact of anti-CRISPR proteins in suppressing the CRISPR-Cas host defense pathway.

  时间:4月17日(周二)11:15-12:30

  地点:图书馆一楼演讲厅

  主持人:雷鸣 教授

 

 

 

 

 

 

 

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