2011年10月9日上午，上海交通大学医学院检验系有幸邀请到了美国康奈尔大学钱书兵博士，为09级本科学生讲授了一堂特殊的分子生物学的课。钱书兵博士结合学生的实际情况，以英文为主，中文为辅的形式，由浅入深的介绍了分子生物学的基本原理、常用的实验技术和科研思路。整堂课气氛活跃，妙趣横生，学生们表现出了极高的兴趣，均表示获益良多。

Shu-Bing Qian, Ph.D.

http://qian.human.cornell.edu/index.htm

EDUCATION

2004 – 2006  PostDoc University of North Carolina at Chapel Hill Cell Biology

2000 – 2004  PostDoc National Institutes of Health, NIAID Cell Biology

1997 – 2000  Ph.D. Shanghai Jiaotong University Biochemistry

1994 – 1997  M.Sc. Shanghai Jiaotong University Molecular Biology

ACADEMIC APPOINTMENTS

2008 – present  Assistant Professor

Division of Nutritional Sciences, Cornell University, Ithaca, NY

2006 – 2008   Research Assistant Professor

Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC

2004 – 2006   Research Fellow

Carolina Cardiovascular Biology Center, University of North

Carolina, Chapel Hill, NC

2000 – 2004   Visiting Fellow

Cell Biology Section, Laboratory of Viral Diseases, NIAID, NIH,

Bethesda, MD

1994 – 2000   Research Assistant

Department of Biochemistry & Molecular Biology, Shanghai Jiaotong

University, Shanghai,P.R.China

AWARDS AND HONORS

2005  Gordon Research Conference Travel Awards, Gordon Research Conferences

2003  NIH Fellows Award for Research Excellence (FARE2004)

2002  NIH Fellows Award for Research Excellence (FARE2003)

2000  Young Scientist Travel Fellowship, the Biochemical Society, FEBS, IUBMB

PUBLICATIONS(2006-2011)

1. Conn CS, and Qian SB. Invited review: Nutrient signaling in protein homeostasis. Cell Cycle 2011; 10(12):1940-7QQ QQ
2. Sun J, Conn CS, Han Y, Yeung V, and Qian SB. PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 mRNA translation.  J Biol Chem 2011 ; 286(8):6791-800
3. Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C. mTORC1 links protein quality and quantity control by sensing chaperone availability.  J Biol Chem 2010 ; 285
4. Qian SB, Waldren L, Choudhary N, Klevit RE, Chazin WJ, Patterson C. Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer. J Biol Chem 2009 ; 284(39):26797-802
5. McDonough H, Charles PC, Hilliard EG, Qian SB, Min JN, Portbury AL, Cyr DM, Patterson C. Stress-dependent chip/DAXX interaction suppresses the p53 apoptotic program. J Biol Chem 2009 ; 284(31): 20649-59
6. Xia T , Dimitropoulou C , Zeng J , Antonova GN , Snead C , Venema RC , Fulton D , Qian SB , Patterson C , Papapetropoulos A , Catravas JD . Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. Am J Physiol Heart Circ Physiol 2007; 293:H3080-3087
7. Qian SB , McDonough H , Boellmann F , Cyr DM , Patterson C . CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature 2006 ; 440: 551-555
8. Qian SB , Reits E, Neefjes J, Deslich JM, Bennink JR, and Yewdell JW. Tight linkage between translation and MHC-class I peptide ligand generation implies specialized antigen processing for defective ribosomal products. J Immunol 2006 ; 177: 227-233
9. Qian SB , P rinciotta MF , Bennink JR, Yewdell JW. Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control. J Biol Chem 2006 ; 281(1):392-400