Shanghai ICP for 05052044 Zip code: 200025 Tel：021-63846590
Address: Shanghai, China, South Chongqing Road no. 227
Copyright © 2013 Shanghai jiaotong university school of medicine
Department:Biochemistry and molecularbiology
Research Interest:1.The activation ofboth pro-cathepsin L and pro-MMP2 through the combination oflegumain with integrin,and their over-expression;increased tumorinvasion and metastasis; a subset of cell surface anchored orassociated proteases that are drastically over-expressed in highpercentage of human cancers;2. The mechanism and effect oftumor-associated macrophages (TAMs) in the promotion ofmalignant
Institute: Institute of HealthSciences,Shanghai Jiao Tong University School ofMedicine
Research Interest:Regulation ofmicroRNA and diseases:1. Mechanism of AU-rich Elements directedmRNA degradation on post-tranional gene regulation; 2.Identification of tissue- and cell-specific MicroRNAs incardiovascular systems and their physiological, pathologicalsignificance;
3. Regulation on differentiation of embryonic stem cells tocardiomyocytes, endothelial cells;4. Lipid metabolism and molecularmechanism of atherosclerosis
Research Interest:Both genetic factorsand non-genetic environmental factors involved in the developmentof human common diseases；epigenetic regulation in genetic diseasesand tumors.
Research Interest:1. Signaltransduction networks and epigenetic regulatory pathways involvedin the self-renewal, differentiation and genome instability ofnormal hematopoietic stem cells and leukemia stem cells;2.Molecular mechanisms underlying chemotactic movement ofinflammatory blood cells and metastasis of cancer stem cells；3.Whole animal-based high throughput screen with zebrafish forpotential therapeutic drugs
Email: email@example.com firstname.lastname@example.org
Research Interest:1. Identificationand characterization of cis-acting elements in untranslated region(UTR) of early response genes involved in carcinogenesis and immuneresponse;2. Post-tranional regulation of immediate earlygenes response to drug treatment;3. Analysis ofpost-tranional mechanism activated by signal transductionpathway that regulates gene expression;4. Development of novelstrategy for ligand screening on expressed drug targetprotein.
Research Interest:Signal transductionin immunity
Research Interest:1. Molecularmechanisms of activation-induced cell death in T cellsubpopulations; 2. Understanding how immunosuppression is mediatedmesenchymal stem cells;3. Tumor stroma and tumorimmunology
Research Interest:1. Identifying thefactors, genes and signal pathways which regulate stem celldifferentiation, especially the differentiation of embryonic stemcells into cardiomyocytes;2. Characterizing embryonic stemcell-derived cardiomyocytes and evaluating their therapeuticimplication;3. Elucidating the regulatory mechanisms of Ca2+signaling and the signal transduction pathways mediated by Gprotein coupled receptors in cardiogenesis and in myocardialcontraction;4. Determining the cellular and molecular basis forhypoxic adaptation-induced cardioprotection against ischemicinjury.
Institute: Institute of HealthSciences, Shanghai Jiao Tong University School ofMedicine